Yes-associated protein 1 (YAP1) promotes human gallbladder tumor growth via activation of the AXL/MAPK pathway
Highlights • Nuclear overexpression of YAP1 was linked to poor prognosis with GBC. • This study examined the mechanistic roles of YAP1 in GBC. • YAP1 promotes GBC cell growth via activation of the AXL/MAPK pathway. • This work provided a rationale for YAP1 as a therapeutic target for GBC.
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Published in: | Cancer letters 2014-12, Vol.355 (2), p.201-209 |
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Main Authors: | , , , , , , , , , , , , , , , , |
Format: | Article |
Language: | eng |
Subjects: | |
Online Access: | Get full text |
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Summary: | Highlights • Nuclear overexpression of YAP1 was linked to poor prognosis with GBC. • This study examined the mechanistic roles of YAP1 in GBC. • YAP1 promotes GBC cell growth via activation of the AXL/MAPK pathway. • This work provided a rationale for YAP1 as a therapeutic target for GBC. |
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ISSN: | 0304-3835 1872-7980 |