Effects of Bisoprolol and Losartan Treatment in the Hypertrophic and Failing Right Heart

Abstract Background Sympathetic adrenergic stimulation and the renin-angiotensin-aldosterone system are highly elevated in right heart failure. We evaluated if treatment with the adrenergic receptor blocker bisoprolol or the angiotensin II receptor blocker losartan could prevent the progression of r...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cardiac failure 2014-11, Vol.20 (11), p.864-873
Main Authors: Andersen, Stine, MS, Schultz, Jacob Gammelgaard, MS, Andersen, Asger, MD, PhD, Ringgaard, Steffen, PhD, Nielsen, Jan M., MD, PhD, Holmboe, Sarah, MD, Vildbrad, Mads D., MS, de Man, Frances S., PhD, Bogaard, Harm J., MD, PhD, Vonk-Noordegraaf, Anton, MD, PhD, Nielsen-Kudsk, Jens Erik, MD, DMSc
Format: Article
Language:English
Subjects:
Adrenergic beta-1 Receptor Antagonists - therapeutic use
angiotensin II receptor blocker
Angiotensin II Type 1 Receptor Blockers - therapeutic use
Animals
beta-adrenergic receptor blocker
Bisoprolol - therapeutic use
Cardiovascular
Disease Models, Animal
Disease Progression
Drug Therapy, Combination
Heart Failure - drug therapy
Heart Failure - physiopathology
Hypertrophy, Right Ventricular - drug therapy
Hypertrophy, Right Ventricular - physiopathology
Losartan - therapeutic use
Male
pulmonary hypertension
Rats
Rats, Wistar
Right ventricular dysfunction
Ventricular Function, Right - drug effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Background Sympathetic adrenergic stimulation and the renin-angiotensin-aldosterone system are highly elevated in right heart failure. We evaluated if treatment with the adrenergic receptor blocker bisoprolol or the angiotensin II receptor blocker losartan could prevent the progression of right ventricular (RV) hypertrophy and failure in rats after pulmonary trunk banding (PTB). Methods and Results Male Wistar rats were randomized to severe PTB with a 0.5-mm banding clip (PTB0.5, n = 29), moderate PTB with a 0.6-mm banding clip (PTB0.6, n = 28), or sham operation (SHAM, n = 13). The PTB0.5 and PTB0.6 rats were randomized to 6 weeks of 10 mg/kg/d bisoprolol treatment, 20 mg/kg/d losartan treatment, or vehicle treatment. The PTB caused hypertrophy, dilation, and reduced function of the RV in all rats subjected to the procedure. Rats subjected to the more severe banding developed decompensated RV failure with extracardiac manifestations. Treatment with bisoprolol slowed the heart rate, and treatment with losartan lowered mean arterial pressure, confirming adequate dosing, but none of the treatments improved RV function or arrested the progression of RV hypertrophy and failure compared with vehicle. Conclusions In our PTB model of pressure overload–induced RV hypertrophy and failure, treatment with bisoprolol and losartan did not demonstrate any beneficial effects in compensated or decompensated RV failure.
ISSN:1071-9164
1532-8414
DOI:10.1016/j.cardfail.2014.08.003