Overexpression of EZH2 associates with a poor prognosis in chronic lymphocytic leukemia

EZH2, a histone methyltransferase, is overexpressed in several human tumors, but whether it exerts any impact in chronic lymphocytic leukemia (CLL) remains unknown. We used real time PCR to investigate the expression profile of EZH1 and EZH2 in 59 CLL patients, 10 samples of purified B-cells from he...

Full description

Saved in:
Bibliographic Details
Published in:Blood cells, molecules, & diseases molecules, & diseases, 2015-01, Vol.54 (1), p.97-102
Main Authors: Rabello, Doralina do Amaral, Lucena-Araujo, Antonio Roberto, Alves-Silva, Juliana Carvalho Rocha, da Eira, Vinícius Burnett Aboud Souza, de Vasconcellos, Maria Catarina Cals, de Oliveira, Fábio Morato, Rego, Eduardo Magalhaes, Saldanha-Araujo, Felipe, Pittella Silva, Fábio
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Chronic lymphocytic leukemia
Cytogenetic
Enhancer of Zeste Homolog 2 Protein
EZH2
Female
Gene expression
Gene Expression Regulation, Enzymologic
Gene Expression Regulation, Leukemic
Histone methyltransferase
Humans
Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis
Leukemia, Lymphocytic, Chronic, B-Cell - enzymology
Male
Middle Aged
Polycomb Repressive Complex 2 - biosynthesis
Prognosis
Real-Time Polymerase Chain Reaction
ZAP-70 Protein-Tyrosine Kinase - biosynthesis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:EZH2, a histone methyltransferase, is overexpressed in several human tumors, but whether it exerts any impact in chronic lymphocytic leukemia (CLL) remains unknown. We used real time PCR to investigate the expression profile of EZH1 and EZH2 in 59 CLL patients, 10 samples of purified B-cells from healthy donors and 12 normal adult tissues. EZH2 was overexpressed in CLL patients and correlates with high white blood cell count, ZAP-70 expression and chromosomal abnormalities. EHZ1 expression does not correlate with CLL progression. EZH2 overexpression is related to a poor prognosis of CLL and could be a useful tool to assess its aggressiveness.
ISSN:1079-9796
1096-0961
DOI:10.1016/j.bcmd.2014.07.013