High sodium intake during postnatal phases induces an increase in arterial blood pressure in adult rats

Epigenetic studies suggest that diseases that develop in adulthood are related to certain conditions to which the individual is exposed during the initial stages of life. Experimental evidence has demonstrated that offspring born to mothers maintained on high-Na diets during pregnancy have higher me...

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Bibliographic Details
Published in:British journal of nutrition 2014-12, Vol.112 (12), p.1923-1932
Main Authors: Moreira, M. C. S., da Silva, E. F., Silveira, L. L., de Paiva, Y. B., de Castro, C. H., Freiria-Oliveira, A. H., Rosa, D. A., Ferreira, P. M., Xavier, C. H., Colombari, E., Pedrino, Gustavo R.
Format: Article
Language:English
Subjects:
Animal Nutritional Physiological Phenomena
Animals
Animals, Newborn
Arterial hypertension. Arterial hypotension
Arterial Pressure
Baroreflex
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Cardiovascular disease
Developmental Biology
Diet
Energy Intake
Experimental diseases
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Furosemide
Heart Rate
Humans
Hypertension
Hypertension - etiology
Infant Nutritional Physiological Phenomena
Infant, Newborn
Male
Medical sciences
Nutrition research
Rats, Wistar
Sodium
Sodium - administration & dosage
Sodium - pharmacology
Sodium Chloride, Dietary - administration & dosage
Sodium Chloride, Dietary - pharmacology
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:Epigenetic studies suggest that diseases that develop in adulthood are related to certain conditions to which the individual is exposed during the initial stages of life. Experimental evidence has demonstrated that offspring born to mothers maintained on high-Na diets during pregnancy have higher mean arterial pressure (MAP) in adulthood. Although these studies have demonstrated the importance of prenatal phases to hypertension development, no evidence regarding the role of high Na intake during postnatal phases in the development of this pathology has been reported. Therefore, in the present study, the effects of Na overload during childhood on induced water and Na intakes and on cardiovascular parameters in adulthood were evaluated. Experiments were carried out in two groups of 21-d-old rats: experimental group, maintained on hypertonic saline (0·3 m-NaCl) solution and food for 60 d, and control group, maintained on tap water and food. Later, both groups were given water and food for 15 d (recovery period). After the recovery period, chronic cannulation of the right femoral artery was performed in unanaesthetised rats to record baseline MAP and heart rate (HR). The experimental group was found to have increased basal MAP (98·6 (sem 2·6) v. 118·3 (sem 2·7) mmHg, P
ISSN:0007-1145
1475-2662
DOI:10.1017/S0007114514002918