Oxidative Stress, Trace Elements, and Circulating Microparticles in Patients With Gaucher Disease Before and After Enzyme Replacement Therapy

We studied the level of lipid peroxide, nitric oxide (NO), trace elements (TEs), and microparticles (MPs) in Gaucher disease (GD) before and after 1 year of enzyme replacement therapy (ERT). A total of 15 children with GD and 15 healthy controls were enrolled in this study. Serum level of lipid pero...

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Bibliographic Details
Published in:Clinical and applied thrombosis/hemostasis 2015-01, Vol.21 (1), p.58-65
Main Authors: Zahran, Asmaa M., Elsayh, Khalid I., El-Deek, Sahar E.M., El-Baz, Mona A.H.
Format: Article
Language:English
Subjects:
Case-Control Studies
Cell-Derived Microparticles - drug effects
Child
Child, Preschool
Copper - blood
Enzyme Replacement Therapy
Enzymes
Female
Gaucher Disease - blood
Gaucher Disease - drug therapy
Glucosylceramidase - therapeutic use
Hexosaminidases - blood
Humans
Lipid Peroxides - blood
Lipids
Male
Nitric Oxide - blood
Oxidative stress
Oxidative Stress - drug effects
Selenium - blood
Trace Elements - blood
Zinc - blood
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Summary:We studied the level of lipid peroxide, nitric oxide (NO), trace elements (TEs), and microparticles (MPs) in Gaucher disease (GD) before and after 1 year of enzyme replacement therapy (ERT). A total of 15 children with GD and 15 healthy controls were enrolled in this study. Serum level of lipid peroxide, NO, and TEs was determined. The MPs were detected by flow cytometry. The level of lipid peroxide was significantly higher in the patients than in the controls even after ERT. Although NO level was normalized in the patients after ERT, zinc and copper were still lower in the patients after ERT. The percentages of various MPs were significantly higher in the patients than in the controls both before and after ERT. There were positive correlations between chitotriosidase and both lipid peroxide and total MPs. Conclusion: The GD is associated with alteration in oxidant and antioxidant status and high level of circulating MPs.
ISSN:1076-0296
1938-2723
DOI:10.1177/1076029613489595