Degree of hydronephrosis predicts adverse pathological features and worse oncologic outcomes in patients with high-grade urothelial carcinoma of the upper urinary tract

Abstract Objective To evaluate degree of hydronephrosis (HN) as a surrogate for adverse pathological features and oncologic outcomes in patients with high-grade (HG) and low-grade (LG) upper tract urothelial carcinomas (UTUCs). Methods We retrospectively reviewed 141 patients with localized UTUCs th...

Full description

Saved in:

Bibliographic Details
Published in:	Urologic oncology 2014-10, Vol.32 (7), p.981-988
Main Authors:	Chung, Paul H., M.D, Krabbe, Laura-Maria, M.D, Darwish, Oussama M., M.D, Westerman, Mary E., B.A, Bagrodia, Aditya, M.D, Gayed, Bishoy A., M.D, Haddad, Ahmed Q., M.D, Kapur, Payal, M.D, Sagalowsky, Arthur I., M.D, Lotan, Yair, M.D, Margulis, Vitaly, M.D
Format:	Article
Language:	eng
Subjects:	Adult Aged Aged, 80 and over Carcinoma, Transitional Cell - complications Carcinoma, Transitional Cell - mortality Carcinoma, Transitional Cell - pathology Chemotherapy Female Humans Hydronephrosis Hydronephrosis - etiology Hydronephrosis - pathology Kaplan-Meier Estimate Kidney Neoplasms - complications Kidney Neoplasms - mortality Kidney Neoplasms - pathology Kidney Pelvis - pathology Male Middle Aged Neoplasm Grading Nephroureterectomy Outcome Proportional Hazards Models Retrospective Studies Upper tract urothelial carcinoma Ureteral Neoplasms - complications Ureteral Neoplasms - mortality Ureteral Neoplasms - pathology Urology
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Abstract Objective To evaluate degree of hydronephrosis (HN) as a surrogate for adverse pathological features and oncologic outcomes in patients with high-grade (HG) and low-grade (LG) upper tract urothelial carcinomas (UTUCs). Methods We retrospectively reviewed 141 patients with localized UTUCs that underwent extirpative surgery at a tertiary referral center. Preoperative imaging was used to evaluate presence and degree of ipsilateral HN. We evaluated degree of HN (none/mild vs. moderate/severe), pathological findings, and oncologic outcomes. Results HG UTUC was present in 113 (80%) patients, muscle-invasive disease (≥pT2) in 49 (35%), and non–organ-confined disease (≥pT3) in 41 (29%). At a median follow-up of 34 months, 49 (35%) patients experienced intravesical recurrence, 28 (20%) developed local/systemic recurrence, and 24 (17%) died of UTUC. HN was graded as none/mild in 77 (55%) patients and moderate/severe in 64 (45%). In patients with HG UTUC, but not LG, degree of HN was associated with advanced pathological stage ( P
ISSN:	1078-1439 1873-2496