The association between multimorbidity and poor adherence with cardiovascular medications

Abstract Multimorbidity, defined as the presence of two or more chronic conditions, leads to a substantial public health burden. This study evaluated its association with adherence with cardiovascular medications in a Chinese population. A proportional stratified sampling was adopted to draw a repre...

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Bibliographic Details
Published in:International journal of cardiology 2014-12, Vol.177 (2), p.477-482
Main Authors: Wong, Martin C.S, Liu, Jing, Zhou, Shenglai, Li, Shiwei, Su, Xuefen, Wang, Harry H.X, Chung, Roger Y.N, Yip, Benjamin H.K, Wong, Samuel Y.S, Lau, Joseph T.F
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Antihypertensive Agents - therapeutic use
Associated factors
Biological and medical sciences
Cardiology. Vascular system
Cardiovascular
Cardiovascular Agents - therapeutic use
Cardiovascular Diseases - drug therapy
Cardiovascular Diseases - epidemiology
Cardiovascular medications
Comorbidity
Data Collection - methods
Depression - drug therapy
Depression - epidemiology
Female
Heart
Humans
Male
Medical sciences
Medication Adherence
Middle Aged
Multimorbidity
Neoplasms - drug therapy
Neoplasms - epidemiology
Population Surveillance - methods
Young Adult
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Summary:Abstract Multimorbidity, defined as the presence of two or more chronic conditions, leads to a substantial public health burden. This study evaluated its association with adherence with cardiovascular medications in a Chinese population. A proportional stratified sampling was adopted to draw a representative sample of residents living in Henan Province, China. Interviewer-administered surveys were conducted by trained researchers. The outcomes included the number of chronic medical conditions, adherence with long-term medications (MMAS-8), and depressive symptoms (CESD-20). Binary logistic regression analysis was conducted to evaluate if medication adherence was associated with the presence of multimorbidity. From a total of 3866 completed surveys, the proportion of subjects having 0, 1 and ≥ 2 chronic conditions was 62.6%, 23.8% and 13.5%, respectively. Among 27.6% who were taking chronic medications, 66.6% had poor medication adherence (MMAS-8 score ≤ 6). From binary logistic regression analysis, subjects with poor medication adherence were significantly associated with multimorbidity (adjusted odds ratio [AOR]: 1.35, 95% C.I. 1.02–1.78, p = 0.037). Other associated factors included older age (AOR = 1.04, 95% C.I. 1.03–1.05, p < 0.001), smoking (AOR = 1.63, 95% C.I. 1.16–2.30, p = 0.005), family history of hypertension (AOR = 1.51, 95% C.I. 1.19–1.93, p = 0.001), and fair to poor self-perceived health status (AOR = 2.15, 95% C.I. 1.69–2.74, p < 0.001). Using medication adherence as the outcome variable, multimorbidity was significantly associated with poor drug adherence (AOR = 1.34, 95% C.I. 1.02–1.77, p = 0.037). Multimorbidity was associated with poorer medication adherence. This implies the need for closer monitoring of the medication taking behavior among those with multiple chronic conditions.
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2014.09.103