Administering 25-hydroxyvitamin D3 in vitamin D-deficient young type 1A diabetic patients reduces reactivity against islet autoantigens

Summary Background & aims We investigated whether improving 25-hydroxyvitamin D status in young type 1A diabetic patients reduces reactivity of peripheral blood mononuclear cells against islet autoantigens and associates with beta-cell functional changes. Methods Eight patients with 25-hydroxyvi...

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Bibliographic Details
Published in:Clinical nutrition (Edinburgh, Scotland) Scotland), 2014-12, Vol.33 (6), p.1153-1156
Main Authors: Federico, G, Focosi, D, Marchi, B, Randazzo, E, De Donno, M, Vierucci, F, Bugliani, M, Campi, F, Scatena, F, Saggese, G, Mathieu, C, Marchetti, P
Format: Article
Language:English
Subjects:
25-Hydroxyvitamin D
Adolescent
Autoantigens - metabolism
Biological and medical sciences
C-Peptide - metabolism
Calcifediol - administration & dosage
Calcifediol - blood
Child
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - drug therapy
Diabetes. Impaired glucose tolerance
ELISpot
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Gastroenterology and Hepatology
Glutamate Decarboxylase - metabolism
Humans
Insulin-Secreting Cells - drug effects
Insulin-Secreting Cells - metabolism
Interferon-gamma - metabolism
Interferon-γ
Leukocytes, Mononuclear - drug effects
Leukocytes, Mononuclear - metabolism
Male
Medical sciences
Proinsulin - metabolism
Type 1A diabetes mellitus
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vitamin D
Vitamin D Deficiency - blood
Vitamin D Deficiency - drug therapy
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Summary:Summary Background & aims We investigated whether improving 25-hydroxyvitamin D status in young type 1A diabetic patients reduces reactivity of peripheral blood mononuclear cells against islet autoantigens and associates with beta-cell functional changes. Methods Eight patients with 25-hydroxyvitamin D deficiency (
ISSN:0261-5614
1532-1983
DOI:10.1016/j.clnu.2014.01.001