Have the American College of Surgeons Oncology Group Z0011 trial results influenced the number of lymph nodes removed during sentinel lymph node dissection?

Abstract Background The American College of Surgeons Oncology Group Z0011 trial results have the potential to bias the number of sentinel lymph nodes (SLNs) surgeons remove and axillary lymph node dissections (ALNDs) performed. Methods A single-institution prospectively collected database was querie...

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Bibliographic Details
Published in:The American journal of surgery 2014-12, Vol.208 (6), p.1060-1064
Main Authors: Robinson, Kristin A., M.D, Pockaj, Barbara A., M.D, Wasif, Nabil, M.D, Kaufman, Katie, Gray, Richard J., M.D
Format: Article
Language:English
Subjects:
ACOSOG Z0011 trial
Adult
Age
Aged
Aged, 80 and over
Axilla
Axillary lymph node dissection
Biopsy
Breast cancer
Breast Neoplasms - pathology
Breast Neoplasms - surgery
Cancer therapies
Clinical Trials as Topic
Confidence intervals
Dissection
Female
Humans
Lymph Node Excision
Lymph Nodes - pathology
Lymph Nodes - surgery
Lymphatic system
Mastectomy, Segmental
Middle Aged
Neoplasm Staging
Oncology
Patients
Prognosis
Prospective Studies
Sentinel Lymph Node Biopsy
Societies, Medical
Surgeon bias
Surgery
Survival Rate
Tumors
United States
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Summary:Abstract Background The American College of Surgeons Oncology Group Z0011 trial results have the potential to bias the number of sentinel lymph nodes (SLNs) surgeons remove and axillary lymph node dissections (ALNDs) performed. Methods A single-institution prospectively collected database was queried for T1 to T2 clinically node-negative breast cancer patients. Results A total of 923 patients underwent breast conserving therapy with SLN biopsy. The mean number of SLNs retrieved before the trial's presentation (June 2010) was 2.7 compared with 2.6 after ( P  = .19). The mean number of SLNs retrieved before the trial's publication (February 2011) was 2.7 compared with 2.5 after ( P = .10). Overall, the rate of completion ALND in patients with SLN macrometastases decreased from after presentation (84% to 63%; P < .01) and publication (83% to 62%; P < .01). Conclusions There was no difference in the number of SLNs harvested after either the Z0011 trial presentation or publication; however, surgeons should be aware of the potential for bias. The trial appears to influence practice management with fewer completion ALNDs performed after its release.
ISSN:0002-9610
1879-1883
DOI:10.1016/j.amjsurg.2014.08.009