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Evaluation of factors associated with prolonged hospital stay and outcome of febrile neutropenic patients receiving chemotherapy: 70 cases (1997-2010)
Febrile neutropenia (FN) is an important sequela in veterinary patients receiving chemotherapy. The purpose of this study was to identify factors associated with prolonged hospital stay and outcome in canine patients developing FN secondary to chemotherapy administration. Medical records of 70 dogs...
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| Published in: | Veterinary & comparative oncology 2014-12, Vol.12 (4), p.266-276 |
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| cited_by | cdi_FETCH-LOGICAL-c3961-8d777cd12072a83dd6ee12316009ada06a38cc7bd06d9e34570be5f1c17051b33 |
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| cites | cdi_FETCH-LOGICAL-c3961-8d777cd12072a83dd6ee12316009ada06a38cc7bd06d9e34570be5f1c17051b33 |
| container_end_page | 276 |
| container_issue | 4 |
| container_start_page | 266 |
| container_title | Veterinary & comparative oncology |
| container_volume | 12 |
| creator | Britton, B. M. Kelleher, M. E. Gregor, T. P. Sorenmo, K. U. |
| description | Febrile neutropenia (FN) is an important sequela in veterinary patients receiving chemotherapy. The purpose of this study was to identify factors associated with prolonged hospital stay and outcome in canine patients developing FN secondary to chemotherapy administration. Medical records of 70 dogs treated for FN at the University of Pennsylvania from 1997 to 2010 were retrospectively evaluated. The mean interval between chemotherapy and hospitalization was 7 days. Two‐thirds of treated patients had lymphoma. The majority of patients (70%) received vincristine or doxorubicin prior to the development of FN. Tachycardia at admission, complicating medical issues, G‐CSF use and decreasing neutrophil count after admission were associated with prolonged hospital stay. Hypotension and G‐CSF use were significantly associated with death in‐hospital. Mortality was 8.5%. Identification of factors associated with prolonged hospital stay and mortality in patients with FN may enable the development of risk‐adapted treatment guidelines to minimize chemotherapy‐associated morbidity and mortality. |
| doi_str_mv | 10.1111/vco.12001 |
| format | article |
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M. ; Kelleher, M. E. ; Gregor, T. P. ; Sorenmo, K. U.</creator><creatorcontrib>Britton, B. M. ; Kelleher, M. E. ; Gregor, T. P. ; Sorenmo, K. U.</creatorcontrib><description>Febrile neutropenia (FN) is an important sequela in veterinary patients receiving chemotherapy. The purpose of this study was to identify factors associated with prolonged hospital stay and outcome in canine patients developing FN secondary to chemotherapy administration. Medical records of 70 dogs treated for FN at the University of Pennsylvania from 1997 to 2010 were retrospectively evaluated. The mean interval between chemotherapy and hospitalization was 7 days. Two‐thirds of treated patients had lymphoma. The majority of patients (70%) received vincristine or doxorubicin prior to the development of FN. Tachycardia at admission, complicating medical issues, G‐CSF use and decreasing neutrophil count after admission were associated with prolonged hospital stay. Hypotension and G‐CSF use were significantly associated with death in‐hospital. Mortality was 8.5%. Identification of factors associated with prolonged hospital stay and mortality in patients with FN may enable the development of risk‐adapted treatment guidelines to minimize chemotherapy‐associated morbidity and mortality.</description><identifier>ISSN: 1476-5810</identifier><identifier>EISSN: 1476-5829</identifier><identifier>DOI: 10.1111/vco.12001</identifier><identifier>PMID: 22998454</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Antineoplastic Agents - adverse effects ; Antineoplastic Agents - therapeutic use ; Antineoplastic Combined Chemotherapy Protocols - adverse effects ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; chemotherapy ; Chemotherapy-Induced Febrile Neutropenia - complications ; Chemotherapy-Induced Febrile Neutropenia - mortality ; Chemotherapy-Induced Febrile Neutropenia - veterinary ; Comorbidity ; Dog Diseases - drug therapy ; Dog Diseases - etiology ; Dog Diseases - mortality ; Dogs ; Female ; fever ; G-CSF ; Hospitals, Animal ; Length of Stay - statistics & numerical data ; Logistic Models ; lymphoma ; Lymphoma - complications ; Lymphoma - drug therapy ; Lymphoma - veterinary ; Male ; Neoplasms - classification ; Neoplasms - complications ; Neoplasms - drug therapy ; Neoplasms - veterinary ; neutropenia ; Pennsylvania - epidemiology ; Retrospective Studies ; Risk Factors ; Schools, Veterinary ; Tachycardia - complications ; Treatment Outcome</subject><ispartof>Veterinary & comparative oncology, 2014-12, Vol.12 (4), p.266-276</ispartof><rights>2012 Blackwell Publishing Ltd</rights><rights>2012 Blackwell Publishing Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3961-8d777cd12072a83dd6ee12316009ada06a38cc7bd06d9e34570be5f1c17051b33</citedby><cites>FETCH-LOGICAL-c3961-8d777cd12072a83dd6ee12316009ada06a38cc7bd06d9e34570be5f1c17051b33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fvco.12001$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fvco.12001$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,786,790,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22998454$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Britton, B. M.</creatorcontrib><creatorcontrib>Kelleher, M. E.</creatorcontrib><creatorcontrib>Gregor, T. P.</creatorcontrib><creatorcontrib>Sorenmo, K. U.</creatorcontrib><title>Evaluation of factors associated with prolonged hospital stay and outcome of febrile neutropenic patients receiving chemotherapy: 70 cases (1997-2010)</title><title>Veterinary & comparative oncology</title><addtitle>Vet Comp Oncol</addtitle><description>Febrile neutropenia (FN) is an important sequela in veterinary patients receiving chemotherapy. The purpose of this study was to identify factors associated with prolonged hospital stay and outcome in canine patients developing FN secondary to chemotherapy administration. Medical records of 70 dogs treated for FN at the University of Pennsylvania from 1997 to 2010 were retrospectively evaluated. The mean interval between chemotherapy and hospitalization was 7 days. Two‐thirds of treated patients had lymphoma. The majority of patients (70%) received vincristine or doxorubicin prior to the development of FN. Tachycardia at admission, complicating medical issues, G‐CSF use and decreasing neutrophil count after admission were associated with prolonged hospital stay. Hypotension and G‐CSF use were significantly associated with death in‐hospital. Mortality was 8.5%. Identification of factors associated with prolonged hospital stay and mortality in patients with FN may enable the development of risk‐adapted treatment guidelines to minimize chemotherapy‐associated morbidity and mortality.</description><subject>Animals</subject><subject>Antineoplastic Agents - adverse effects</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Antineoplastic Combined Chemotherapy Protocols - adverse effects</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>chemotherapy</subject><subject>Chemotherapy-Induced Febrile Neutropenia - complications</subject><subject>Chemotherapy-Induced Febrile Neutropenia - mortality</subject><subject>Chemotherapy-Induced Febrile Neutropenia - veterinary</subject><subject>Comorbidity</subject><subject>Dog Diseases - drug therapy</subject><subject>Dog Diseases - etiology</subject><subject>Dog Diseases - mortality</subject><subject>Dogs</subject><subject>Female</subject><subject>fever</subject><subject>G-CSF</subject><subject>Hospitals, Animal</subject><subject>Length of Stay - statistics & numerical data</subject><subject>Logistic Models</subject><subject>lymphoma</subject><subject>Lymphoma - complications</subject><subject>Lymphoma - drug therapy</subject><subject>Lymphoma - veterinary</subject><subject>Male</subject><subject>Neoplasms - classification</subject><subject>Neoplasms - complications</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - veterinary</subject><subject>neutropenia</subject><subject>Pennsylvania - epidemiology</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Schools, Veterinary</subject><subject>Tachycardia - complications</subject><subject>Treatment Outcome</subject><issn>1476-5810</issn><issn>1476-5829</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNp1kctu1DAUhi0EohdY8ALIy3aR1pckdtihUTsFlVZCXCQ2lmOfdAxJnNrOlHkStn0WngzDtLPDG9vS93_SOT9Cryg5ofmcro0_oYwQ-gTt01LURSVZ83T3pmQPHcT4nRDGSs6eoz3GmkaWVbmPfp2tdT_r5PyIfYc7bZIPEesYvXE6gcV3Lq3wFHzvx5v8Xfk4uaR7HJPeYD1a7Odk_AA5_vu-gza4HvAIcwp-gtEZPGU7jCniAAbc2o032Kxg8GkFQU-bN1gQbHSEiI9o04iCEUqOX6Bnne4jvHy4D9Hn87NPi4vi8nr5bvH2sjC8qWkhrRDC2Dy8YFpya2sAyjitCWm01aTWXBojWktq2wAvK0FaqDpqqCAVbTk_REdbb57wdoaY1OCigb7XI_g5KlozyUpKpczo8RY1wccYoFNTcIMOG0WJ-tuDyj2ofz1k9vWDdm4HsDvycfEZON0Cd3ldm_-b1JfF9aOy2CZcTPBzl9Dhh6oFF5X6erVUH0glL5bvv6mP_A9Op6Kj</recordid><startdate>201412</startdate><enddate>201412</enddate><creator>Britton, B. M.</creator><creator>Kelleher, M. E.</creator><creator>Gregor, T. P.</creator><creator>Sorenmo, K. U.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201412</creationdate><title>Evaluation of factors associated with prolonged hospital stay and outcome of febrile neutropenic patients receiving chemotherapy: 70 cases (1997-2010)</title><author>Britton, B. M. ; Kelleher, M. E. ; Gregor, T. P. ; Sorenmo, K. U.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3961-8d777cd12072a83dd6ee12316009ada06a38cc7bd06d9e34570be5f1c17051b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - adverse effects</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Antineoplastic Combined Chemotherapy Protocols - adverse effects</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>chemotherapy</topic><topic>Chemotherapy-Induced Febrile Neutropenia - complications</topic><topic>Chemotherapy-Induced Febrile Neutropenia - mortality</topic><topic>Chemotherapy-Induced Febrile Neutropenia - veterinary</topic><topic>Comorbidity</topic><topic>Dog Diseases - drug therapy</topic><topic>Dog Diseases - etiology</topic><topic>Dog Diseases - mortality</topic><topic>Dogs</topic><topic>Female</topic><topic>fever</topic><topic>G-CSF</topic><topic>Hospitals, Animal</topic><topic>Length of Stay - statistics & numerical data</topic><topic>Logistic Models</topic><topic>lymphoma</topic><topic>Lymphoma - complications</topic><topic>Lymphoma - drug therapy</topic><topic>Lymphoma - veterinary</topic><topic>Male</topic><topic>Neoplasms - classification</topic><topic>Neoplasms - complications</topic><topic>Neoplasms - drug therapy</topic><topic>Neoplasms - veterinary</topic><topic>neutropenia</topic><topic>Pennsylvania - epidemiology</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Schools, Veterinary</topic><topic>Tachycardia - complications</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Britton, B. M.</creatorcontrib><creatorcontrib>Kelleher, M. E.</creatorcontrib><creatorcontrib>Gregor, T. P.</creatorcontrib><creatorcontrib>Sorenmo, K. U.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary & comparative oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Britton, B. M.</au><au>Kelleher, M. E.</au><au>Gregor, T. P.</au><au>Sorenmo, K. U.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of factors associated with prolonged hospital stay and outcome of febrile neutropenic patients receiving chemotherapy: 70 cases (1997-2010)</atitle><jtitle>Veterinary & comparative oncology</jtitle><addtitle>Vet Comp Oncol</addtitle><date>2014-12</date><risdate>2014</risdate><volume>12</volume><issue>4</issue><spage>266</spage><epage>276</epage><pages>266-276</pages><issn>1476-5810</issn><eissn>1476-5829</eissn><notes>istex:75C7CEBD88304ACA80090E282364418BED5EDA7F</notes><notes>ArticleID:VCO12001</notes><notes>ark:/67375/WNG-M058HGJZ-R</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Febrile neutropenia (FN) is an important sequela in veterinary patients receiving chemotherapy. The purpose of this study was to identify factors associated with prolonged hospital stay and outcome in canine patients developing FN secondary to chemotherapy administration. Medical records of 70 dogs treated for FN at the University of Pennsylvania from 1997 to 2010 were retrospectively evaluated. The mean interval between chemotherapy and hospitalization was 7 days. Two‐thirds of treated patients had lymphoma. The majority of patients (70%) received vincristine or doxorubicin prior to the development of FN. Tachycardia at admission, complicating medical issues, G‐CSF use and decreasing neutrophil count after admission were associated with prolonged hospital stay. Hypotension and G‐CSF use were significantly associated with death in‐hospital. Mortality was 8.5%. Identification of factors associated with prolonged hospital stay and mortality in patients with FN may enable the development of risk‐adapted treatment guidelines to minimize chemotherapy‐associated morbidity and mortality.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>22998454</pmid><doi>10.1111/vco.12001</doi><tpages>11</tpages></addata></record> |
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| ispartof | Veterinary & comparative oncology, 2014-12, Vol.12 (4), p.266-276 |
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| source | Wiley-Blackwell Journals |
| subjects | Animals Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use chemotherapy Chemotherapy-Induced Febrile Neutropenia - complications Chemotherapy-Induced Febrile Neutropenia - mortality Chemotherapy-Induced Febrile Neutropenia - veterinary Comorbidity Dog Diseases - drug therapy Dog Diseases - etiology Dog Diseases - mortality Dogs Female fever G-CSF Hospitals, Animal Length of Stay - statistics & numerical data Logistic Models lymphoma Lymphoma - complications Lymphoma - drug therapy Lymphoma - veterinary Male Neoplasms - classification Neoplasms - complications Neoplasms - drug therapy Neoplasms - veterinary neutropenia Pennsylvania - epidemiology Retrospective Studies Risk Factors Schools, Veterinary Tachycardia - complications Treatment Outcome |
| title | Evaluation of factors associated with prolonged hospital stay and outcome of febrile neutropenic patients receiving chemotherapy: 70 cases (1997-2010) |
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