Evaluation of factors associated with prolonged hospital stay and outcome of febrile neutropenic patients receiving chemotherapy: 70 cases (1997-2010)

Febrile neutropenia (FN) is an important sequela in veterinary patients receiving chemotherapy. The purpose of this study was to identify factors associated with prolonged hospital stay and outcome in canine patients developing FN secondary to chemotherapy administration. Medical records of 70 dogs...

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Bibliographic Details
Published in:Veterinary & comparative oncology 2014-12, Vol.12 (4), p.266-276
Main Authors: Britton, B. M., Kelleher, M. E., Gregor, T. P., Sorenmo, K. U.
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - adverse effects
Antineoplastic Agents - therapeutic use
Antineoplastic Combined Chemotherapy Protocols - adverse effects
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
chemotherapy
Chemotherapy-Induced Febrile Neutropenia - complications
Chemotherapy-Induced Febrile Neutropenia - mortality
Chemotherapy-Induced Febrile Neutropenia - veterinary
Comorbidity
Dog Diseases - drug therapy
Dog Diseases - etiology
Dog Diseases - mortality
Dogs
Female
fever
G-CSF
Hospitals, Animal
Length of Stay - statistics & numerical data
Logistic Models
lymphoma
Lymphoma - complications
Lymphoma - drug therapy
Lymphoma - veterinary
Male
Neoplasms - classification
Neoplasms - complications
Neoplasms - drug therapy
Neoplasms - veterinary
neutropenia
Pennsylvania - epidemiology
Retrospective Studies
Risk Factors
Schools, Veterinary
Tachycardia - complications
Treatment Outcome
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Summary:Febrile neutropenia (FN) is an important sequela in veterinary patients receiving chemotherapy. The purpose of this study was to identify factors associated with prolonged hospital stay and outcome in canine patients developing FN secondary to chemotherapy administration. Medical records of 70 dogs treated for FN at the University of Pennsylvania from 1997 to 2010 were retrospectively evaluated. The mean interval between chemotherapy and hospitalization was 7 days. Two‐thirds of treated patients had lymphoma. The majority of patients (70%) received vincristine or doxorubicin prior to the development of FN. Tachycardia at admission, complicating medical issues, G‐CSF use and decreasing neutrophil count after admission were associated with prolonged hospital stay. Hypotension and G‐CSF use were significantly associated with death in‐hospital. Mortality was 8.5%. Identification of factors associated with prolonged hospital stay and mortality in patients with FN may enable the development of risk‐adapted treatment guidelines to minimize chemotherapy‐associated morbidity and mortality.
ISSN:1476-5810
1476-5829
DOI:10.1111/vco.12001