Polidocanol inhibits cowhage - but not histamine-induced itch in humans

Polidocanol is a local anaesthetic and antipruritic compound that is used in the treatment of itching skin conditions such as eczema. Its mechanisms of action are largely ill defined. This study has compared the antipruritic efficacy of topical polidocanol in histamine‐induced itch and a histamine‐i...

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Bibliographic Details
Published in:Experimental dermatology 2014-12, Vol.23 (12), p.922-923
Main Authors: Hawro, Tomasz, Fluhr, Joachim W., Mengeaud, Valérie, Redoulès, Daniel, Church, Martin K., Maurer, Marcus, Metz, Martin
Format: Article
Language:English
Subjects:
Adult
antipruritics
Antipruritics - therapeutic use
atopic dermatitis
Double-Blind Method
Female
Histamine - physiology
Histamine - toxicity
Humans
Male
Middle Aged
mucuna
Mucuna - enzymology
Mucuna - toxicity
polidocanol
Polyethylene Glycols - therapeutic use
pruritus
Pruritus - drug therapy
Pruritus - etiology
Pruritus - physiopathology
Receptor, PAR-2 - physiology
Receptors, Thrombin - physiology
Young Adult
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Summary:Polidocanol is a local anaesthetic and antipruritic compound that is used in the treatment of itching skin conditions such as eczema. Its mechanisms of action are largely ill defined. This study has compared the antipruritic efficacy of topical polidocanol in histamine‐induced itch and a histamine‐independent, cowhage‐induced model of pruritus. Polidocanol (3%) or vehicle was applied topically under occlusion for 1 h to the forearms of 45 healthy volunteers before itch was provoked by rubbing in 40–45 spicules of cowhage or skin prick testing with 10 mg/ml histamine. Itch was recorded at 1‐min intervals for 30 min on a 100‐mm visual analogue scale. Polidocanol significantly reduced the area under the curve for cowhage‐induced itch by 58% (P 
ISSN:0906-6705
1600-0625
DOI:10.1111/exd.12555