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Five-year fracture risk estimation in patients with Parkinson's disease
Abstract Background Previous studies have shown that patients with Parkinson's disease (PD) are at increased risk of fractures. However, no specific prediction model for fracture estimation among PD patients is currently available. Therefore, the aim of this study was to develop a simple score...
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| Published in: | Bone (New York, N.Y.) N.Y.), 2013-10, Vol.56 (2), p.266-270 |
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| container_title | Bone (New York, N.Y.) |
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| creator | Pouwels, Sander Bazelier, Marloes T de Boer, Anthonius Weber, Wim E.J Neef, C. (Kees) Cooper, Cyrus de Vries, Frank |
| description | Abstract Background Previous studies have shown that patients with Parkinson's disease (PD) are at increased risk of fractures. However, no specific prediction model for fracture estimation among PD patients is currently available. Therefore, the aim of this study was to develop a simple score for estimating the 5-year osteoporotic and hip fracture risks among patients with PD. Methods The UK Clinical Practice Research Datalink (1987–2011) was used to identify incident PD patients. Cox proportional-hazards models were used to calculate the 5-year risks of osteoporotic and hip fracture among PD patients. The regression model was fitted with various risk factors for fracture and the final Cox model was converted into integer risk scores. Results We identified 4411 incident PD patients without a history of osteoporotic treatment. The 5-year risks of osteoporotic and hip fracture were plotted in relation to the risk score. Risk scores increased with age, female gender, history of renal disease and history of dementia. The C-statistic, which is a parameter to test the internal validity of the model, was reasonable for the prediction of osteoporotic fracture (0.69) and hip fracture (0.73). Conclusion In this study, we developed a simple model to estimate 5-year fracture risk among incident PD patients. It may be useful in daily practice after external validation. |
| doi_str_mv | 10.1016/j.bone.2013.06.018 |
| format | article |
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(Kees) ; Cooper, Cyrus ; de Vries, Frank</creator><creatorcontrib>Pouwels, Sander ; Bazelier, Marloes T ; de Boer, Anthonius ; Weber, Wim E.J ; Neef, C. (Kees) ; Cooper, Cyrus ; de Vries, Frank</creatorcontrib><description>Abstract Background Previous studies have shown that patients with Parkinson's disease (PD) are at increased risk of fractures. However, no specific prediction model for fracture estimation among PD patients is currently available. Therefore, the aim of this study was to develop a simple score for estimating the 5-year osteoporotic and hip fracture risks among patients with PD. Methods The UK Clinical Practice Research Datalink (1987–2011) was used to identify incident PD patients. Cox proportional-hazards models were used to calculate the 5-year risks of osteoporotic and hip fracture among PD patients. The regression model was fitted with various risk factors for fracture and the final Cox model was converted into integer risk scores. Results We identified 4411 incident PD patients without a history of osteoporotic treatment. The 5-year risks of osteoporotic and hip fracture were plotted in relation to the risk score. Risk scores increased with age, female gender, history of renal disease and history of dementia. The C-statistic, which is a parameter to test the internal validity of the model, was reasonable for the prediction of osteoporotic fracture (0.69) and hip fracture (0.73). Conclusion In this study, we developed a simple model to estimate 5-year fracture risk among incident PD patients. It may be useful in daily practice after external validation.</description><identifier>ISSN: 8756-3282</identifier><identifier>EISSN: 1873-2763</identifier><identifier>DOI: 10.1016/j.bone.2013.06.018</identifier><identifier>PMID: 23800516</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Epidemiology ; Female ; Fracture ; Fractures, Bone - epidemiology ; Fundamental and applied biological sciences. Psychology ; Humans ; Injuries of the limb. Injuries of the spine ; Male ; Medical sciences ; Middle Aged ; Models, Theoretical ; Neurology ; Orthopedics ; Osteoporotic Fractures - epidemiology ; Parkinson Disease - epidemiology ; Parkinson's disease ; Prevention ; Traumas. Diseases due to physical agents ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Bone (New York, N.Y.), 2013-10, Vol.56 (2), p.266-270</ispartof><rights>Elsevier Inc.</rights><rights>2013 Elsevier Inc.</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2013 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-8bf27c60cc0cd755f125e489149cea46f2e4a84ecf9eb743a231d962385547f83</citedby><cites>FETCH-LOGICAL-c474t-8bf27c60cc0cd755f125e489149cea46f2e4a84ecf9eb743a231d962385547f83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27721030$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23800516$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pouwels, Sander</creatorcontrib><creatorcontrib>Bazelier, Marloes T</creatorcontrib><creatorcontrib>de Boer, Anthonius</creatorcontrib><creatorcontrib>Weber, Wim E.J</creatorcontrib><creatorcontrib>Neef, C. (Kees)</creatorcontrib><creatorcontrib>Cooper, Cyrus</creatorcontrib><creatorcontrib>de Vries, Frank</creatorcontrib><title>Five-year fracture risk estimation in patients with Parkinson's disease</title><title>Bone (New York, N.Y.)</title><addtitle>Bone</addtitle><description>Abstract Background Previous studies have shown that patients with Parkinson's disease (PD) are at increased risk of fractures. However, no specific prediction model for fracture estimation among PD patients is currently available. Therefore, the aim of this study was to develop a simple score for estimating the 5-year osteoporotic and hip fracture risks among patients with PD. Methods The UK Clinical Practice Research Datalink (1987–2011) was used to identify incident PD patients. Cox proportional-hazards models were used to calculate the 5-year risks of osteoporotic and hip fracture among PD patients. The regression model was fitted with various risk factors for fracture and the final Cox model was converted into integer risk scores. Results We identified 4411 incident PD patients without a history of osteoporotic treatment. The 5-year risks of osteoporotic and hip fracture were plotted in relation to the risk score. Risk scores increased with age, female gender, history of renal disease and history of dementia. The C-statistic, which is a parameter to test the internal validity of the model, was reasonable for the prediction of osteoporotic fracture (0.69) and hip fracture (0.73). Conclusion In this study, we developed a simple model to estimate 5-year fracture risk among incident PD patients. It may be useful in daily practice after external validation.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Fracture</subject><subject>Fractures, Bone - epidemiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Injuries of the limb. Injuries of the spine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Models, Theoretical</subject><subject>Neurology</subject><subject>Orthopedics</subject><subject>Osteoporotic Fractures - epidemiology</subject><subject>Parkinson Disease - epidemiology</subject><subject>Parkinson's disease</subject><subject>Prevention</subject><subject>Traumas. Diseases due to physical agents</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>8756-3282</issn><issn>1873-2763</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqFkk2LFDEQhoMo7rj6BzxIX0QvPVY-OkmDCLK4q7CgoJ5DJl2NmelJj6nulfn3pplRwYOeksPzVqqeFGNPOaw5cP1qu96MCdcCuFyDXgO399iKWyNrYbS8z1bWNLqWwooL9ohoCwCyNfwhuxDSAjRcr9jNdbzD-og-V332YZozVjnSrkKa4t5PcUxVTNWh3DBNVP2I07fqk8-7mGhML6jqIqEnfMwe9H4gfHI-L9nX63dfrt7Xtx9vPly9va2DMmqq7aYXJmgIAUJnmqbnokFlW67agF7pXqDyVmHoW9wYJb2QvGt16bdplOmtvGQvT3UPefw-lybdPlLAYfAJx5kc18K01rQl-19UFTMGeGsKKk5oyCNRxt4dcpk-Hx0Ht7h2W7e4dotrB9oV1yX07Fx_3uyx-x35JbcAz8-Ap-CH4jeFSH84YwQHCYV7feKwiLuLmB2FYjtgFzOGyXVj_Hcfb_6KhyGmWF7c4RFpO845lS9x3JFw4D4vW7EsBZcAQmotfwJR77CT</recordid><startdate>20131001</startdate><enddate>20131001</enddate><creator>Pouwels, Sander</creator><creator>Bazelier, Marloes T</creator><creator>de Boer, Anthonius</creator><creator>Weber, Wim E.J</creator><creator>Neef, C. (Kees)</creator><creator>Cooper, Cyrus</creator><creator>de Vries, Frank</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QP</scope></search><sort><creationdate>20131001</creationdate><title>Five-year fracture risk estimation in patients with Parkinson's disease</title><author>Pouwels, Sander ; Bazelier, Marloes T ; de Boer, Anthonius ; Weber, Wim E.J ; Neef, C. (Kees) ; Cooper, Cyrus ; de Vries, Frank</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-8bf27c60cc0cd755f125e489149cea46f2e4a84ecf9eb743a231d962385547f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Fracture</topic><topic>Fractures, Bone - epidemiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Injuries of the limb. Injuries of the spine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Models, Theoretical</topic><topic>Neurology</topic><topic>Orthopedics</topic><topic>Osteoporotic Fractures - epidemiology</topic><topic>Parkinson Disease - epidemiology</topic><topic>Parkinson's disease</topic><topic>Prevention</topic><topic>Traumas. Diseases due to physical agents</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pouwels, Sander</creatorcontrib><creatorcontrib>Bazelier, Marloes T</creatorcontrib><creatorcontrib>de Boer, Anthonius</creatorcontrib><creatorcontrib>Weber, Wim E.J</creatorcontrib><creatorcontrib>Neef, C. (Kees)</creatorcontrib><creatorcontrib>Cooper, Cyrus</creatorcontrib><creatorcontrib>de Vries, Frank</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><jtitle>Bone (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pouwels, Sander</au><au>Bazelier, Marloes T</au><au>de Boer, Anthonius</au><au>Weber, Wim E.J</au><au>Neef, C. (Kees)</au><au>Cooper, Cyrus</au><au>de Vries, Frank</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Five-year fracture risk estimation in patients with Parkinson's disease</atitle><jtitle>Bone (New York, N.Y.)</jtitle><addtitle>Bone</addtitle><date>2013-10-01</date><risdate>2013</risdate><volume>56</volume><issue>2</issue><spage>266</spage><epage>270</epage><pages>266-270</pages><issn>8756-3282</issn><eissn>1873-2763</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Abstract Background Previous studies have shown that patients with Parkinson's disease (PD) are at increased risk of fractures. However, no specific prediction model for fracture estimation among PD patients is currently available. Therefore, the aim of this study was to develop a simple score for estimating the 5-year osteoporotic and hip fracture risks among patients with PD. Methods The UK Clinical Practice Research Datalink (1987–2011) was used to identify incident PD patients. Cox proportional-hazards models were used to calculate the 5-year risks of osteoporotic and hip fracture among PD patients. The regression model was fitted with various risk factors for fracture and the final Cox model was converted into integer risk scores. Results We identified 4411 incident PD patients without a history of osteoporotic treatment. The 5-year risks of osteoporotic and hip fracture were plotted in relation to the risk score. Risk scores increased with age, female gender, history of renal disease and history of dementia. The C-statistic, which is a parameter to test the internal validity of the model, was reasonable for the prediction of osteoporotic fracture (0.69) and hip fracture (0.73). Conclusion In this study, we developed a simple model to estimate 5-year fracture risk among incident PD patients. It may be useful in daily practice after external validation.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>23800516</pmid><doi>10.1016/j.bone.2013.06.018</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Epidemiology Female Fracture Fractures, Bone - epidemiology Fundamental and applied biological sciences. Psychology Humans Injuries of the limb. Injuries of the spine Male Medical sciences Middle Aged Models, Theoretical Neurology Orthopedics Osteoporotic Fractures - epidemiology Parkinson Disease - epidemiology Parkinson's disease Prevention Traumas. Diseases due to physical agents Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Five-year fracture risk estimation in patients with Parkinson's disease |
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