Five-year fracture risk estimation in patients with Parkinson's disease

Abstract Background Previous studies have shown that patients with Parkinson's disease (PD) are at increased risk of fractures. However, no specific prediction model for fracture estimation among PD patients is currently available. Therefore, the aim of this study was to develop a simple score...

Full description

Saved in:
Bibliographic Details
Published in:Bone (New York, N.Y.) N.Y.), 2013-10, Vol.56 (2), p.266-270
Main Authors: Pouwels, Sander, Bazelier, Marloes T, de Boer, Anthonius, Weber, Wim E.J, Neef, C. (Kees), Cooper, Cyrus, de Vries, Frank
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Epidemiology
Female
Fracture
Fractures, Bone - epidemiology
Fundamental and applied biological sciences. Psychology
Humans
Injuries of the limb. Injuries of the spine
Male
Medical sciences
Middle Aged
Models, Theoretical
Neurology
Orthopedics
Osteoporotic Fractures - epidemiology
Parkinson Disease - epidemiology
Parkinson's disease
Prevention
Traumas. Diseases due to physical agents
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Background Previous studies have shown that patients with Parkinson's disease (PD) are at increased risk of fractures. However, no specific prediction model for fracture estimation among PD patients is currently available. Therefore, the aim of this study was to develop a simple score for estimating the 5-year osteoporotic and hip fracture risks among patients with PD. Methods The UK Clinical Practice Research Datalink (1987–2011) was used to identify incident PD patients. Cox proportional-hazards models were used to calculate the 5-year risks of osteoporotic and hip fracture among PD patients. The regression model was fitted with various risk factors for fracture and the final Cox model was converted into integer risk scores. Results We identified 4411 incident PD patients without a history of osteoporotic treatment. The 5-year risks of osteoporotic and hip fracture were plotted in relation to the risk score. Risk scores increased with age, female gender, history of renal disease and history of dementia. The C-statistic, which is a parameter to test the internal validity of the model, was reasonable for the prediction of osteoporotic fracture (0.69) and hip fracture (0.73). Conclusion In this study, we developed a simple model to estimate 5-year fracture risk among incident PD patients. It may be useful in daily practice after external validation.
ISSN:8756-3282
1873-2763
DOI:10.1016/j.bone.2013.06.018