Linking pathways in the developing and aging brain with neurodegeneration

Highlights • We review common pathways of the developing and aging brain. • Proteins that are important in neurodegeneration play a role in the developing brain. • Understanding neurogenesis has implications for reversing neurodegeneration. • Prevention of age-related neurodegeneration might begin d...

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Bibliographic Details
Published in:Neuroscience 2014-06, Vol.269, p.152-172
Main Authors: Kovacs, G.G, Adle-Biassette, H, Milenkovic, I, Cipriani, S, van Scheppingen, J, Aronica, E
Format: Article
Language:English
Subjects:
Aging - physiology
Animals
Biological and medical sciences
brain
Brain - growth & development
Brain - physiology
Brain - physiopathology
development
developmental pathways
Fundamental and applied biological sciences. Psychology
human
Humans
neurodegeneration
neurodegenerative disease-associated proteins
Neurodegenerative Diseases - physiopathology
Neurogenesis - physiology
Neurology
Signal Transduction - physiology
Vertebrates: nervous system and sense organs
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Summary:Highlights • We review common pathways of the developing and aging brain. • Proteins that are important in neurodegeneration play a role in the developing brain. • Understanding neurogenesis has implications for reversing neurodegeneration. • Prevention of age-related neurodegeneration might begin during the fetal life.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2014.03.045