Altered acetylcholine release in the hippocampus of dystrophin-deficient mice

Highlights • Dystrophin is not expressed in Duchenne muscle dystrophy and mdx mice. • nAChR-evoked [3 H]-ACh release was enhanced in the hippocampus of 12-month-old mdx mice. • The level of vesicular ACh transporter was marginally reduced in the hippocampus. • [3 H]-ACh release evoked by K+ depolari...

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Bibliographic Details
Published in:Neuroscience 2014-06, Vol.269, p.173-183
Main Authors: Parames, S.F, Coletta-Yudice, E.D, Nogueira, F.M, Nering de Sousa, M.B, Hayashi, M.A, Lima-Landman, M.T.R, Lapa, A.J, Souccar, C
Format: Article
Language:English
Subjects:
[3H]-ACh release
Acetylcholine - metabolism
Animals
Biological and medical sciences
Blotting, Western
Cerebellum - drug effects
Cerebellum - growth & development
Cerebellum - metabolism
Cerebral Cortex - drug effects
Cerebral Cortex - growth & development
Cerebral Cortex - metabolism
dystrophin
Dystrophin - deficiency
Dystrophin - physiology
Fundamental and applied biological sciences. Psychology
hippocampus
Hippocampus - drug effects
Hippocampus - growth & development
Hippocampus - metabolism
Male
mdx mouse
Mice, Inbred C57BL
Mice, Inbred mdx
Neurology
nicotinic acetylcholine receptor
Nicotinic Antagonists - pharmacology
Potassium Chloride - metabolism
Receptors, Nicotinic - metabolism
Synaptosomes - drug effects
Synaptosomes - metabolism
Vertebrates: nervous system and sense organs
Vesicular Acetylcholine Transport Proteins - metabolism
vesicular ACh transporter
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Summary:Highlights • Dystrophin is not expressed in Duchenne muscle dystrophy and mdx mice. • nAChR-evoked [3 H]-ACh release was enhanced in the hippocampus of 12-month-old mdx mice. • The level of vesicular ACh transporter was marginally reduced in the hippocampus. • [3 H]-ACh release evoked by K+ depolarization was not altered in the hippocampus. • Dystrophin deficiency may be associated with altered nicotinic synaptic function.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2014.03.050