Anti-tumor activity of human IgG1 anti-gp75 TA99 mAb against B16F10 melanoma in human FcgammaRI transgenic mice

Highlights • Human IgG1 anti-gp75 TA99 mAb shows normal target binding and functional in in vitro ADCC. • Human IgG1 TA99 mAb does not prevent outgrowth of B16F10 melanoma in wild type mice. • Anti-tumor effects of human IgG1 TA99 mAb against B16F10 melanoma in human FcgammaRI transgenic mice and Fc...

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Bibliographic Details
Published in:Immunology letters 2014-08, Vol.160 (2), p.151-157
Main Authors: Boross, Peter, Jansen, J.H. Marco, van Tetering, Geert, Nederend, Maaike, Brandsma, Arianne, Meyer, Saskia, Torfs, Ellen, van den Ham, Henk-Jan, Meulenbroek, Laura, de Haij, Simone, Leusen, Jeanette H.W
Format: Article
Language:English
Subjects:
Allergy and Immunology
Amino Acid Sequence
Animals
Antibodies, Monoclonal - chemistry
Antibodies, Monoclonal - genetics
Antibodies, Monoclonal - pharmacology
Antibody therapy
Cross Reactions
Fc receptor
gp75
Humans
Hybridomas - chemistry
Hybridomas - immunology
Immunoglobulin G - chemistry
Immunoglobulin G - genetics
Immunoglobulin G - pharmacology
Melanoma
Melanoma, Experimental - immunology
Melanoma, Experimental - pathology
Melanoma, Experimental - therapy
Membrane Glycoproteins - antagonists & inhibitors
Membrane Glycoproteins - genetics
Membrane Glycoproteins - immunology
Mice
Mice, Transgenic
Molecular Sequence Data
Oxidoreductases - antagonists & inhibitors
Oxidoreductases - genetics
Oxidoreductases - immunology
Receptors, IgG - deficiency
Receptors, IgG - genetics
Receptors, IgG - immunology
Recombinant Fusion Proteins - chemistry
Recombinant Fusion Proteins - genetics
Recombinant Fusion Proteins - pharmacology
Skin Neoplasms - immunology
Skin Neoplasms - pathology
Skin Neoplasms - therapy
TA99
Transgenes
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Summary:Highlights • Human IgG1 anti-gp75 TA99 mAb shows normal target binding and functional in in vitro ADCC. • Human IgG1 TA99 mAb does not prevent outgrowth of B16F10 melanoma in wild type mice. • Anti-tumor effects of human IgG1 TA99 mAb against B16F10 melanoma in human FcgammaRI transgenic mice and FcgRIIB knockout mice.
ISSN:0165-2478
1879-0542
1879-0542
DOI:10.1016/j.imlet.2014.02.005