Somatostatin receptor-mediated suppression of gabaergic synaptic transmission in cultured rat retinal amacrine cells

Highlights • SRIF suppresses the sIPSC frequency in cultured rat GABAergic amacrine cells. • The SRIF effect on the sIPSCs is partially mediated by sst5 /sst2 receptors. • SRIF suppresses the sIPSCs through inhibiting presynaptic Ca2+ channels. • Intracellular cAMP–PKA signaling pathway mediates the...

Full description

Saved in:
Bibliographic Details
Published in:Neuroscience 2014-07, Vol.273, p.118-127
Main Authors: Chen, W, Ke, J.-B, Wu, H.-J, Miao, Y, Li, F, Yang, X.-L, Wang, Z
Format: Article
Language:English
Subjects:
Adenylyl Cyclases - metabolism
Amacrine Cells - drug effects
Amacrine Cells - physiology
Animals
Biological and medical sciences
calcium channels
Calcium Channels - metabolism
cAMP–PKA signaling pathway
Cells, Cultured
Cyclic AMP - metabolism
Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors
Cyclic AMP-Dependent Protein Kinases - metabolism
Eye and associated structures. Visual pathways and centers. Vision
Fundamental and applied biological sciences. Psychology
gamma-Aminobutyric Acid - metabolism
Inhibitory Postsynaptic Potentials - drug effects
Inhibitory Postsynaptic Potentials - physiology
Inositol 1,4,5-Trisphosphate Receptors - antagonists & inhibitors
Inositol 1,4,5-Trisphosphate Receptors - metabolism
Neurology
patch-clamp
Patch-Clamp Techniques
Presynaptic Terminals - drug effects
Presynaptic Terminals - physiology
Protein Kinase C - antagonists & inhibitors
Protein Kinase C - metabolism
Rats, Sprague-Dawley
Receptors, Somatostatin - antagonists & inhibitors
Receptors, Somatostatin - metabolism
Signal Transduction - drug effects
Somatostatin - metabolism
spontaneous inhibitory postsynaptic currents
Synaptic Transmission - drug effects
Synaptic Transmission - physiology
Vertebrates: nervous system and sense organs
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • SRIF suppresses the sIPSC frequency in cultured rat GABAergic amacrine cells. • The SRIF effect on the sIPSCs is partially mediated by sst5 /sst2 receptors. • SRIF suppresses the sIPSCs through inhibiting presynaptic Ca2+ channels. • Intracellular cAMP–PKA signaling pathway mediates the SRIF effect.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2014.05.013