The novel acute phase protein, IHRP, inhibits actin polymerization and phagocytosis of polymorphonuclear cells

In the present study, the involvement of the binding of IHRP (inter-alpha-trypsin inhibitor family heavy chain-related protein) and actin in phagocyte activity was investigated. The actin polymerization and the phagocytic activity of the polymorphonuclear (PMN) cells were studied in the presence of...

Full description

Saved in:
Bibliographic Details
Published in:Inflammation research 2000-06, Vol.49 (6), p.305-310
Main Authors: Choi-Miura, N H, Takahashi, K, Yoda, M, Saito, K, Hori, M, Ozaki, H, Mazda, T, Tomita, M
Format: Article
Language:English
Subjects:
Actins - metabolism
Blood Proteins - metabolism
Blood Proteins - pharmacology
Carrier Proteins - isolation & purification
Carrier Proteins - metabolism
Glycoproteins - metabolism
Glycoproteins - pharmacology
Humans
Immune Sera - immunology
Neutrophils - drug effects
Neutrophils - physiology
Phagocytosis - drug effects
Polymers - metabolism
Proteinase Inhibitory Proteins, Secretory
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In the present study, the involvement of the binding of IHRP (inter-alpha-trypsin inhibitor family heavy chain-related protein) and actin in phagocyte activity was investigated. The actin polymerization and the phagocytic activity of the polymorphonuclear (PMN) cells were studied in the presence of IHRP. IHRP inhibited the polymerization of actin and the phagocytic activity of the PMN cells. 1) IHRP may bind to actin released from the damaged cells and suppress its toxic action by preventing the formation of actin fibril. 2) IHRP may bind to cell surface actin on PMN cells and inhibit their phagocytic activities. 3) From these results, IHRP may act as an anti-inflammatory protein.
ISSN:1023-3830
1420-908X
DOI:10.1007/pl00000211