Persistent behavioral and neurochemical sensitization to an acute injection of methamphetamine following unpredictable stress

•Stress increases methamphetamine's effects on locomotion.•Stress increases methamphetamine-induced dopamine in the striatum.•Stress increases methamphetamine-induced hyperthermia.•Effects of stress are lasting. Prior research in humans and animals suggest that exposure to chronic stress alters...

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Bibliographic Details
Published in:Behavioural brain research 2014-10, Vol.272, p.308-313
Main Authors: Matuszewich, Leslie, Carter, Samantha, Anderson, Eden M., Friedman, Ross D., McFadden, Lisa M.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Central Nervous System Stimulants - pharmacology
Chromatography, High Pressure Liquid
Corpus Striatum - drug effects
Corpus Striatum - physiopathology
Dopamine
Dopamine - metabolism
Exploratory Behavior - drug effects
Exploratory Behavior - physiology
Fever - chemically induced
Fever - physiopathology
Fundamental and applied biological sciences. Psychology
Hyperthermia
Locomotion
Male
Medical sciences
Methamphetamine
Methamphetamine - pharmacology
Microdialysis
Motor Activity - drug effects
Motor Activity - physiology
Neuropharmacology
Pharmacology. Drug treatments
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Random Allocation
Rats, Sprague-Dawley
Sensitization
Stress, Psychological - physiopathology
Unpredictable stress
Vertebrates: nervous system and sense organs
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Summary:•Stress increases methamphetamine's effects on locomotion.•Stress increases methamphetamine-induced dopamine in the striatum.•Stress increases methamphetamine-induced hyperthermia.•Effects of stress are lasting. Prior research in humans and animals suggest that exposure to chronic stress alters the response to drugs of abuse, increasing vulnerability to drug addiction. Chronic unpredictable stress (CUS) has been shown to augment the increase of dopamine in the striatum when challenged with high doses of methamphetamine immediately following stress exposure, however it is not known whether this neurochemical stress-sensitization continues after the cessation of the stressors or if behavioral sensitization is also present. Therefore, the current study examined the immediate and delayed effects of CUS on methamphetamine-induced behaviors and striatal dopamine levels. Male rats were exposed to 10 days of CUS and then tested in either an open field box to assess locomotion or underwent in vivo microdialysis to measure striatal dopamine levels immediately following CUS or after a 1–2 week delay. All rats exposed to CUS showed a potentiated locomotor response immediately following an acute injection of 7.5mg/kg methamphetamine compared to non-stressed control rats. Both groups of CUS rats also showed augmented dopamine release and rectal temperatures following methamphetamine with prolonged increases in the CUS rats tested after a delay. These results suggest that CUS increases the sensitivity of a rat to a single injection of methamphetamine and that the increased sensitivity persists for up to 2 weeks following the last stressor.
ISSN:0166-4328
1872-7549
DOI:10.1016/j.bbr.2014.07.013