Dynamics of interleukin-21 production during the clinical course of primary and secondary dengue virus infections

Highlights • First report about the involvement of IL-21 during the clinical course of Dengue infections. • Dynamics of IL-21 production in primary and secondary dengue infections. • The highest serum levels of IL-21 are produced during the convalescent phase of primary infections. • Serum levels of...

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Bibliographic Details
Published in:Immunology letters 2014-09, Vol.161 (1), p.89-95
Main Authors: Vivanco-Cid, H, Maldonado-Rentería, M.J, Sánchez-Vargas, L.A, Izaguirre-Hernández, I.Y, Hernández-Flores, K.G, Remes-Ruiz, R
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Allergy and Immunology
Antibodies, Viral - blood
Antibodies, Viral - immunology
Antibody response
Antibody Specificity - immunology
Case-Control Studies
Cellular immunity
Child
Child, Preschool
Dengue
Dengue - diagnosis
Dengue - immunology
Dengue - metabolism
Dengue virus
Dengue Virus - immunology
Female
Humans
Immunoglobulin G - blood
Immunoglobulin G - immunology
Immunoglobulin M - blood
Immunoglobulin M - immunology
Interleukin 21
Interleukins - biosynthesis
Interleukins - blood
Male
Middle Aged
Severity of Illness Index
Young Adult
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Summary:Highlights • First report about the involvement of IL-21 during the clinical course of Dengue infections. • Dynamics of IL-21 production in primary and secondary dengue infections. • The highest serum levels of IL-21 are produced during the convalescent phase of primary infections. • Serum levels of IL-21 correlate with the production of DENV-specific IgM and IgG antibodies. • IL-21 may play a protective role in primary and secondary dengue infections.
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2014.05.006