A slight increase within the normal range of serum uric acid and the decline in renal function: associations in a community-based population

Hyperuricemia is a risk factor for adverse renal outcomes in patients with chronic kidney disease. This study investigated the effect of uric acid on renal function in a community-based population. We used a nationwide database of 165 847 subjects (aged 29-74, male 40%) who participated in the annua...

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Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 2014-12, Vol.29 (12), p.2286-2292
Main Authors: Kamei, Keita, Konta, Tsuneo, Hirayama, Atsushi, Suzuki, Kazuko, Ichikawa, Kazunobu, Fujimoto, Shouichi, Iseki, Kunitoshi, Moriyama, Toshiki, Yamagata, Kunihiro, Tsuruya, Kazuhiko, Kimura, Kenjiro, Narita, Ichiei, Kondo, Masahide, Asahi, Koichi, Watanabe, Tsuyoshi
Format: Article
Language:English
Subjects:
Aged
Female
Follow-Up Studies
Glomerular Filtration Rate
Humans
Hyperuricemia - blood
Hyperuricemia - epidemiology
Hyperuricemia - physiopathology
Japan - epidemiology
Male
Middle Aged
Population Surveillance
Reference Values
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - epidemiology
Renal Insufficiency, Chronic - physiopathology
Retrospective Studies
Risk Factors
Uric Acid - blood
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Summary:Hyperuricemia is a risk factor for adverse renal outcomes in patients with chronic kidney disease. This study investigated the effect of uric acid on renal function in a community-based population. We used a nationwide database of 165 847 subjects (aged 29-74, male 40%) who participated in the annual 'Specific Health Check and Guidance in Japan' checkup between 2008 and 2010; we examined the relationship between serum uric acid levels at baseline and 2-year change in the estimated glomerular filtration rate (eGFR) obtained by using the Japanese equation. After adjusting for possible confounders, the eGFR change was inversely correlated with uric acid at baseline. In the multivariable analysis, the decline in eGFR was significantly more rapid in subjects with the slight increase in uric acid (males ≥5.7 mg/dL, females ≥4.4 mg/dL), and the risk for incidental renal insufficiency (eGFR
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/gfu256