Adaptation of in vivo amino acid kinetics facilitates increased amino acid availability for fetal growth in adolescent and adult pregnancies alike

During pregnancy, adult women with a normal BMI synthesise extra amino acids after an overnight fast by increasing body protein breakdown and decreasing amino acid oxidation. It is not known whether adolescent girls can make these adaptations during pregnancy. The present study aimed to measure and...

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Bibliographic Details
Published in:	British journal of nutrition 2014-12, Vol.112 (11), p.1779-1786
Main Authors:	Thame, Minerva M., Hsu, Jean W., Gibson, Raquel, Baker, Tameka M., Tang, Grace J., Badaloo, Asha V., Fletcher, Horace M., Jackson, Alan A., Jahoor, Farook
Format:	Article
Language:	eng
Subjects:	Adolescent Adult Alanine - blood Amino acids Amino Acids - blood Biological and medical sciences Blood Proteins - metabolism Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Glutamine - blood Humans Infant, Newborn Kinetics Leucine - blood Male Metabolism and Metabolic Studies Oxidation-Reduction Pregnancy Pregnancy - blood Pregnancy in Adolescence - blood Pregnancy Outcome Pregnancy Trimesters - blood Prenatal development Teenagers Vertebrates: anatomy and physiology, studies on body, several organs or systems Women
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Summary:	During pregnancy, adult women with a normal BMI synthesise extra amino acids after an overnight fast by increasing body protein breakdown and decreasing amino acid oxidation. It is not known whether adolescent girls can make these adaptations during pregnancy. The present study aimed to measure and compare the protein, glutamine and alanine kinetics of adult women and adolescent girls at early-, mid- and late-pregnancy. Kinetics were measured in the overnight fasted state using intravenous infusions of 13C-leucine, 15N-glutamine and 15N-alanine in ten adults and twenty adolescents aged 14–17 years in the first and second trimesters (phase 1 study) and infusions of 13C-leucine and 15N2-urea in ten adults and eleven adolescents aged 16–17 years in the first and third trimesters (phase 2 study). In phase 1 study, there were no significant differences between the groups with regard to any of the kinetic parameters measured. In both groups, leucine flux increased (P
ISSN:	0007-1145 1475-2662