Quantitative muscle ultrasound versus quantitative magnetic resonance imaging in facioscapulohumeral dystrophy

ABSTRACT Introduction: Ultrasound and magnetic resonance imaging (MRI) are non‐invasive methods that can be performed repeatedly and without discomfort. In the assessment of neuromuscular disorders it is unknown if they provide complementary information. In this study we tested this for patients wit...

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Bibliographic Details
Published in:Muscle & nerve 2014-12, Vol.50 (6), p.968-975
Main Authors: Janssen, Barbara H., Pillen, Sigrid, Voet, Nicoline B.M., Heerschap, Arend, van Engelen, Baziel G.M., van Alfen, Nens
Format: Article
Language:English
Subjects:
Adult
Disease Progression
fascioscapulohumeral muscular dystrophy
Humans
Leg
Magnetic Resonance Imaging - methods
Male
method comparison
Middle Aged
MRI
Muscle, Skeletal - diagnostic imaging
Muscle, Skeletal - pathology
Muscular dystrophy
Muscular Dystrophy, Facioscapulohumeral - diagnosis
Muscular Dystrophy, Facioscapulohumeral - diagnostic imaging
Muscular Dystrophy, Facioscapulohumeral - pathology
NMR
Nuclear magnetic resonance
Pilot Projects
quantitative imaging
quantitative muscle ultrasound
Reproducibility of Results
Sensitivity and Specificity
Severity of Illness Index
Ultrasonic imaging
Ultrasonography - methods
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Summary:ABSTRACT Introduction: Ultrasound and magnetic resonance imaging (MRI) are non‐invasive methods that can be performed repeatedly and without discomfort. In the assessment of neuromuscular disorders it is unknown if they provide complementary information. In this study we tested this for patients with facioscapulohumeral muscular dystrophy (FSHD). Methods: We performed quantitative muscle ultrasound (QMUS) and quantitative MRI (QMRI) of the legs in 5 men with FSHD. Results: The correlation between QMUS‐determined z‐scores and QMRI‐determined muscle fraction and T1 signal intensity (SI) was very high. QMUS had a wider dynamic range than QMRI, whereas QMRI could detect inhomogeneous distribution of pathology over the length of the muscles. Conclusions: Both QMUS and QMRI are well suited for imaging muscular dystrophy. The wider dynamic range of QMUS can be advantageous in the follow‐up of advanced disease stages, whereas QMRI seems preferable in pathologies such as FSHD that affect deep muscle layers and show inhomogeneous abnormality distributions. Muscle Nerve 50: 968–975, 2014
ISSN:0148-639X
1097-4598
DOI:10.1002/mus.24247