Mesenchymal stromal cell density is increased in higher grade myelodysplastic syndromes and independently predicts survival

We retrospectively tested the prognostic and diagnostic significance of CD271+ mesenchymal stromal cell (MSC) density in cytopenic patients who underwent bone marrow biopsy to evaluate for myelodysplastic syndromes (MDS). CD271+ MSC density was quantitated by automated image analysis of tissue micro...

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Bibliographic Details
Published in:American journal of clinical pathology 2014-12, Vol.142 (6), p.795-802
Main Authors: Johnson, Ryan C, Kurzer, Jason H, Greenberg, Peter L, Gratzinger, Dita
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Female
Humans
Kaplan-Meier Estimate
Male
Mesenchymal Stromal Cells - pathology
Middle Aged
Myelodysplastic syndromes
Myelodysplastic Syndromes - mortality
Myelodysplastic Syndromes - pathology
Prognosis
Proportional Hazards Models
Retrospective Studies
Tissue Array Analysis
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Summary:We retrospectively tested the prognostic and diagnostic significance of CD271+ mesenchymal stromal cell (MSC) density in cytopenic patients who underwent bone marrow biopsy to evaluate for myelodysplastic syndromes (MDS). CD271+ MSC density was quantitated by automated image analysis of tissue microarray cores in 125 cytopenic patients: 40 lower grade MDS (
ISSN:0002-9173
1943-7722
DOI:10.1309/ajcp71ophkotlsug