Lymphatic-targeted cationic liposomes: A robust vaccine adjuvant for promoting long-term immunological memory

Highlights • OVA antigen was encapsulated with mannosylated DOTAP liposomes (LP-Man) to generate lymphatic-targeted liposome vaccines. • LP-Man vaccines showed increased accumulation in secondary lymphoid organs and enhanced uptake by antigen-presenting cells. • LP-Man vaccines led to vigorous and p...

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Bibliographic Details
Published in:Vaccine 2014-09, Vol.32 (42), p.5475-5483
Main Authors: Wang, Ce, Liu, Peng, Zhuang, Yan, Li, Ping, Jiang, Boling, Pan, Hong, Liu, Lanlan, Cai, Lintao, Ma, Yifan
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Antigen-Presenting Cells - immunology
Applied microbiology
B-Lymphocytes - immunology
Biological and medical sciences
CD4-Positive T-Lymphocytes - immunology
Cells, Cultured
Dendritic Cells - immunology
Drug Delivery Systems
Female
Follicular T helper cells
Fundamental and applied biological sciences. Psychology
Germinal center
Germinal Center - immunology
Immune system
Immunologic Memory
Immunological memory
Liposome vaccine
Liposomes - chemistry
Lymph Nodes - immunology
Lymphatic system
Lymphatic targeting
Mice, Inbred BALB C
Mice, Inbred C57BL
Microbiology
Ovalbumin - immunology
Polyethylene glycol
Spleen - immunology
Studies
Vaccines
Vaccines - chemistry
Vaccines - immunology
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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Summary:Highlights • OVA antigen was encapsulated with mannosylated DOTAP liposomes (LP-Man) to generate lymphatic-targeted liposome vaccines. • LP-Man vaccines showed increased accumulation in secondary lymphoid organs and enhanced uptake by antigen-presenting cells. • LP-Man vaccines led to vigorous and persistent germinal center responses. • LP-Man vaccines increased Tfh cells and central memory CD4+ T cells in the secondary lymphoid organs. • LP-Man vaccines elicited sustained antibody production and robust recall responses three months after priming.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2014.07.081