Anti-inflammatory effects of Bryophyllum pinnatum (Lam.) Oken ethanol extract in acute and chronic cutaneous inflammation

Bryophyllum pinnatum (Lam.) Oken (Crassulaceae), popularly known in Brazil as “folha-da-fortuna”, is a plant species used in folk medicine for the external and internal treatment of inflammation, infection, wound, burn, boil, ulcers and gastritis, and several other diseases. The present study aimed...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2014-06, Vol.154 (2), p.330-338
Main Authors: Chibli, Lucas A., Rodrigues, Kamilla C.M., Gasparetto, Carolina M., Pinto, Nícolas C.C., Fabri, Rodrigo L., Scio, Elita, Alves, Maria S., Del-Vechio-Vieira, Glauciemar, Sousa, Orlando V.
Format: Article
Language:English
Subjects:
Acute Disease
Animals
Anti-inflammatory
Anti-Inflammatory Agents, Non-Steroidal - isolation & purification
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Arachidonic Acid - pharmacology
Bryophyllum pinnatum
Capsaicin - pharmacology
Chronic Disease
Crassulaceae
Croton
Croton Oil - pharmacology
Dermatitis, Contact - drug therapy
Dermatitis, Contact - etiology
Dermatitis, Contact - immunology
Ear edema
Edema - drug therapy
Edema - immunology
Ethanol - chemistry
Ethnopharmacology
Flavonoids
Herbal medicines
Kalanchoe - chemistry
Kalanchoe - growth & development
Male
Mice
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Plant Leaves - chemistry
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Summary:Bryophyllum pinnatum (Lam.) Oken (Crassulaceae), popularly known in Brazil as “folha-da-fortuna”, is a plant species used in folk medicine for the external and internal treatment of inflammation, infection, wound, burn, boil, ulcers and gastritis, and several other diseases. The present study aimed to perform the chemical characterization and the evaluation of the topical anti-inflammatory effect of the ethanol extract of Bryophyllum pinnatum leaves (EEBP) in acute and chronic mice ear edema models induced by different irritant agents. The EEBP chemical characterization was performed by HPLC–UV DAD. Ear edema on Swiss mice was induced by the topical application of Croton oil (single and multiple applications), arachidonic acid, phenol, capsaicin and ethyl phenylpropiolate (EPP). The topical anti-inflammatory effect of EEBP was evaluated by measuring the ear weight (acute inflammation models) and thickness (chronic inflammation model). Histopathological analyses of ear tissue samples sensitized with Croton oil (single and multiple applications) were also performed. The flavonoids rutin, quercetin, luteolin and luteolin7-O-β-d-glucoside were detected in EEBP. Topical application of EEBP significantly (P
ISSN:0378-8741
1872-7573
DOI:10.1016/j.jep.2014.03.035