Flexible and practical synthesis of 3-oxyindoles through gold-catalyzed intermolecular oxidation of o-ethynylanilines

A novel gold-catalyzed intermolecular oxidation of o-ethynylanilines has been developed. A range of functionalized 3-oxyindoles are readily accessed by utilizing this strategy. Importantly, this gold-catalyzed oxidative process outcompetes the typical indole formation.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2014-08, Vol.50 (63), p.8689-8692
Main Authors: Shu, Chao, Li, Long, Xiao, Xin-Yu, Yu, Yong-Fei, Ping, Yi-Fan, Zhou, Jin-Mei, Ye, Long-Wu
Format: Article
Language:English
Subjects:
Aniline Compounds - chemistry
Catalysis
Cyclization
Formations
Gold - chemistry
Indoles
Indoles - chemistry
Oxidation
Oxidation-Reduction
Strategy
Synthesis
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Description
Summary:A novel gold-catalyzed intermolecular oxidation of o-ethynylanilines has been developed. A range of functionalized 3-oxyindoles are readily accessed by utilizing this strategy. Importantly, this gold-catalyzed oxidative process outcompetes the typical indole formation.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc03565h