Urinary Porphyrins in Patients with Endemic Chronic Arsenic Poisoning Caused by Burning Coal in China

Objective: To evaluate the effect of arsenic (As) on the porphyrin biosynthetic pathway, urine samples from patients with endemic chronic arsenic poisoning were examined. Subjects and Methods: The subjects were 16 patients, who had been exposed to As from burning coal for 8 to 25 years, and-16 contr...

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Published in:Environmental health and preventive medicine 2001, Vol.5 (4), p.180-185
Main Authors: Xie, Yaxiong, Kondo, Masao, Koga, Hidenori, Miyamoto, Hiroshi, Chiba, Momoko
Format: Article
Language:English
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Summary:Objective: To evaluate the effect of arsenic (As) on the porphyrin biosynthetic pathway, urine samples from patients with endemic chronic arsenic poisoning were examined. Subjects and Methods: The subjects were 16 patients, who had been exposed to As from burning coal for 8 to 25 years, and-16 controls living in the same region in Guizhou Province in southwest China. Concentrations of urinary As, porphyrins and ALA were determined by induced coupled plasma mass spectrometry (ICP-MS), high performance liquid chromatography (HPLC) with a reversed-phase column and fluorescence detector, and colorimetric spectrophotometry, respectively. Results: Concentrations of As in patients and controls, 184.40 +/- 200.04 and 86.82 +/- 64.20 mu g/g creatinine (mean +/- SD) respectively, were significantly different (p
ISSN:1342-078X
1347-4715
DOI:10.1265/ehpm.2000.180