Study of the Contribution of the State of Water to the Gel Properties of a Photocrosslinked Polyacrylic Acid Hydrogel using Magnetic Resonance Imaging

Photocrosslinked polyacrylic acid (PAA–HEMA) hydrogels are a promising candidate for use in dermatological patch adhesives. To gain further knowledge about the properties of this gel, we investigated the T1 relaxation time and the diffusion coefficient (D) of water in the hydrogels using magnetic re...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 2014-11, Vol.103 (11), p.3532-3541
Main Authors: Onuki, Yoshinori, Hasegawa, Naoki, Kida, Chihiro, Obata, Yasuko, Takayama, Kozo
Format: Article
Language:English
Subjects:
Adhesives
Analysis of Variance
Bayes Theorem
Bayesian network
Chemistry, Pharmaceutical
Diffusion
diffusion coefficient
hydration
Hydrogels
imaging methods
Magnetic Resonance Imaging
Models, Chemical
MRI
multivariate analysis
Polyhydroxyethyl Methacrylate - chemistry
relaxation time
state of water
Technology, Pharmaceutical - methods
Water - chemistry
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Summary:Photocrosslinked polyacrylic acid (PAA–HEMA) hydrogels are a promising candidate for use in dermatological patch adhesives. To gain further knowledge about the properties of this gel, we investigated the T1 relaxation time and the diffusion coefficient (D) of water in the hydrogels using magnetic resonance (MR) imaging. Hydrogels with different formulations and process factors were prepared and tested. The observed data were analyzed by ANOVA, which clarified the mode of action of the formulation and process factors based on these MR parameters. Various gel properties (i.e., gel fraction, swelling capacity, gel strength, and water-retention ability) were also measured, followed by a Bayesian network (BN) analysis. The BN allowed us to summarize well the relationships between the formulation and process factors, MR parameters, and gel properties. T1 was associated with the swelling and water-retention properties of the hydrogel, whereas D was associated with gel formation and gel strength. Furthermore, this study clarified that T1 and D mostly represented the hydration and water-compartmentalization effects of the hydrogel, respectively. In conclusion, the state of water seems to play an important role in the properties of the PAA–HEMA hydrogel. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 103:3532–3541, 2014
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.24140