3D printing of new biobased unsaturated polyesters by microstereo-thermallithography

New micro three-dimensional (3D) scaffolds using biobased unsaturated polyesters (UPs) were prepared by microstereo-thermal-lithography (μSTLG). This advanced processing technique offers indubitable advantages over traditional printing methods. The accuracy and roughness of the 3D structures were ev...

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Bibliographic Details
Published in:Biofabrication 2014-09, Vol.6 (3), p.035024-035024
Main Authors: Gonçalves, Filipa A M M, Costa, Cátia S M F, Fabela, Inês G P, Farinha, Dina, Faneca, Henrique, Simões, Pedro N, Serra, Arménio C, Bártolo, Paulo J, Coelho, Jorge F J
Format: Article
Language:English
Subjects:
3T3 Cells
Animals
Biocompatible Materials - chemistry
Bioprinting
Cell Adhesion
Fibroblasts - cytology
Hot Temperature
Mice
Polyesters - chemical synthesis
Polyesters - chemistry
Printing, Three-Dimensional
Tensile Strength
Tissue Engineering - instrumentation
Tissue Scaffolds - chemistry
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Summary:New micro three-dimensional (3D) scaffolds using biobased unsaturated polyesters (UPs) were prepared by microstereo-thermal-lithography (μSTLG). This advanced processing technique offers indubitable advantages over traditional printing methods. The accuracy and roughness of the 3D structures were evaluated by scanning electron microscopy and infinite focus microscopy, revealing a suitable roughness for cell attachment. UPs were synthesized by bulk polycondensation between biobased aliphatic diacids (succinic, adipic and sebacic acid) and two different glycols (propylene glycol and diethylene glycol) using fumaric acid as the source of double bonds. The chemical structures of the new oligomers were confirmed by proton nuclear magnetic resonance spectra, attenuated total reflectance Fourier transform infrared spectroscopy and matrix assisted laser desorption/ionization-time of flight mass spectrometry. The thermal and mechanical properties of the UPs were evaluated to determine the influence of the diacid/glycol ratio and the type of diacid in the polyester's properties. In addition an extensive thermal characterization of the polyesters is reported. The data presented in this work opens the possibility for the use of biobased polyesters in additive manufacturing technologies as a route to prepare biodegradable tailor made scaffolds that have potential applications in a tissue engineering area.
ISSN:1758-5090
DOI:10.1088/1758-5082/6/3/035024