Laboratory surveillance for invasive meningococcal disease in Chile, 2006-2012

Laboratory surveillance of Invasive Meningococcal Disease (IMD) is performed by the Institute of Public Health of Chile. It confirms identification, classifies in serogroups and analyzes the genetic profiles of Neisseria meningitidis isolates from laboratories throughout the country. To show the res...

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Bibliographic Details
Published in:Revista chilena de infectología 2014-08, Vol.31 (4), p.377-384
Main Authors: Araya, Pamela, Díaz, Janepsy, Seoane, Mabel, Fernández, Jorge, Terrazas, Solana, Canals, Andrea, Vaquero, Alejandra, Barra, Gisselle, Hormazábal, Juan C, Pidal, Paola, Valenzuela, M Teresa
Format: Article
Language:Spanish
Subjects:
Adolescent
Adult
Anti-Bacterial Agents - pharmacology
Bacterial Typing Techniques
Child
Child, Preschool
Chile - epidemiology
Epidemiological Monitoring
Genotype
Humans
Incidence
Infant
Meningococcal Infections - epidemiology
Meningococcal Infections - microbiology
Microbial Sensitivity Tests
Middle Aged
Neisseria meningitidis - drug effects
Neisseria meningitidis - genetics
Population Surveillance
Young Adult
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Summary:Laboratory surveillance of Invasive Meningococcal Disease (IMD) is performed by the Institute of Public Health of Chile. It confirms identification, classifies in serogroups and analyzes the genetic profiles of Neisseria meningitidis isolates from laboratories throughout the country. To show the results of this surveillance from 2006 to 2012. A descriptive data analysis of the confirmed cases of IMD and serological characterization, susceptibility and genetic profiles of the isolates. The analysis was disaggregated by serogroup, age and region. From 2006 to 2012, 486 isolates of N. meningitidis were confirmed. In 2011 a rise in IMD rates was observed due to an increase in W serogroup cases, mainly affecting children aged 5 years or less. Serogroup W became the most prevalent during 2012 (58.3%), replacing the historically prevalent serogroup B. Predominating strains belonged to ST-32 complex/ET-5 complex (40, 4% of strains) and ST-41/44 complex/ Lineage 3 (45, 9% of strains). Laboratory surveillance has allowed the early detection of increasing IMD caused by serogroup W, which is emergent in Chile. This information has reinforced the daily monitoring of new cases, in collaboration with all the clinical laboratories of the country.
ISSN:0716-1018
0717-6341
DOI:10.4067/S0716-10182014000400001