A meta‐analysis and meta‐regression of outcomes including biliary complications in donation after cardiac death liver transplantation

Summary Donation after cardiac death (DCD) liver transplantation is increasingly common but concerns exist over the development of biliary complications and ischemic cholangiopathy (IC). This study aimed to compare outcomes between DCD and donation after brain death (DBD) liver grafts. Studies repor...

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Bibliographic Details
Published in:Transplant international 2014-11, Vol.27 (11), p.1159-1174
Main Authors: O'Neill, Stephen, Roebuck, Amanda, Khoo, Emily, Wigmore, Stephen J., Harrison, Ewen M.
Format: Article
Language:English
Subjects:
Biliary Tract Diseases - etiology
Brain Death
Death
deceased donors
donation after cardiac death
Female
Graft Survival
Humans
Ischemia - etiology
liver clinical complications
liver clinical outcome
Liver Transplantation - adverse effects
Male
Postoperative Complications - etiology
Regression Analysis
Risk Factors
Tissue Donors
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Summary:Summary Donation after cardiac death (DCD) liver transplantation is increasingly common but concerns exist over the development of biliary complications and ischemic cholangiopathy (IC). This study aimed to compare outcomes between DCD and donation after brain death (DBD) liver grafts. Studies reporting on post‐transplantation outcomes after Maastricht category III DCD liver transplantation were screened for inclusion. Odds ratios (OR) with 95% confidence intervals were produced using random‐effects models for the incidence of biliary complications, IC, graft and recipient survival. Meta‐regression was undertaken to identify between‐study predictors of effect size for biliary complications and IC. PROSPERO Record: CRD42012002113. Twenty‐five studies with 62 184 liver transplant recipients (DCD = 2478 and DBD = 59 706) were included. In comparison with DBD, there was a significant increase in biliary complications [OR = 2.4 (1.9, 3.1); P 
ISSN:0934-0874
1432-2277
DOI:10.1111/tri.12403