Restoration of MBL-deficiency: redefining the safety, efficacy and viability of MBL-substitution therapy

MBL-deficiency is a commonly occurring deficiency of the innate immune system, affecting a substantial part of the population and has been extensively studied. MBL appears to function as a disease modifier. The role of MBL in different conditions is context-dependent. Many clinical studies show conf...

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Bibliographic Details

Published in:	Molecular immunology 2014-10, Vol.61 (2), p.174-184
Main Authors:	Keizer, M P, Wouters, D, Schlapbach, L J, Kuijpers, T W
Format:	Article
Language:	English
Subjects:	Genetic Predisposition to Disease Genotype Humans Mannose-Binding Lectin - chemistry Mannose-Binding Lectin - deficiency Mannose-Binding Lectin - genetics Mannose-Binding Lectin - immunology Mannose-Binding Lectin - metabolism Mannose-Binding Lectin - therapeutic use Mannose-Binding Protein-Associated Serine Proteases - chemistry Mannose-Binding Protein-Associated Serine Proteases - genetics Mannose-Binding Protein-Associated Serine Proteases - metabolism Metabolism, Inborn Errors - therapy Recombinant Proteins - therapeutic use Treatment Outcome
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