Comparison of maternal and umbilical cord blood soluble lectin-like oxidized low-density lipoprotein receptor 1 levels in early- and late-onset preeclampsia

Background The main purpose of this study was to determine the maternal and umbilical cord blood oxidized LDL (oxLDL) and soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) levels in early- and late-onset preeclampsia (PE). Materials and methods A case–control study was conduct...

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Bibliographic Details
Published in:Archives of gynecology and obstetrics 2014-11, Vol.290 (5), p.1007-1013
Main Authors: Tuten, A., Erman, H., Korkmaz, G. G., Oncul, M., Gelisgen, R., Sozer, V., Acıkgoz, S., Simsek, G., Uzun, H.
Format: Article
Language:English
Subjects:
Adult
Blood Pressure
Body Mass Index
Case-Control Studies
Endocrinology
Enzyme-Linked Immunosorbent Assay
Female
Fetal Blood
Fetal Weight
Gestational Age
Gynecologic Endocrinology and Reproductive Medicine
Gynecology
Human Genetics
Humans
Lipoproteins, LDL - blood
Medicine
Medicine & Public Health
Obstetrics/Perinatology/Midwifery
Pre-Eclampsia - blood
Preeclampsia
Pregnancy
Scavenger Receptors, Class E - blood
Umbilical cord
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Summary:Background The main purpose of this study was to determine the maternal and umbilical cord blood oxidized LDL (oxLDL) and soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) levels in early- and late-onset preeclampsia (PE). Materials and methods A case–control study was conducted in pregnant women with early-onset (before 34 weeks’ gestation n  = 19) and late-onset (after 34 weeks’ gestation n  = 22) PE compared to healthy normotensive pregnant controls ( n  = 44). Groups were compared for the maternal and umbilical cord plasma oxLDL and serum sLOX-1 levels. Results The mean maternal and umbilical cord serum sLOX-1 and plasma oxLDL levels were significantly increased in early- and late-onset PE compared to controls ( p  
ISSN:0932-0067
1432-0711
DOI:10.1007/s00404-014-3294-5