Genetic analysis of microtubule motor proteins in Drosophila: a mutation at the ncd locus is a dominant enhancer of nod

The nod (no distributive disjunction) and the ncd (non-claret disjunctional) mutations are both female-specific, recessive meiotic mutations in Drosophila melanogaster. Mutations at either locus show high frequencies of nondisjunction at meiosis I and both have been shown to encode kinesin-like prot...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1991-08, Vol.88 (16), p.7165-7169
Main Authors: Knowles, B.A. (Albert Einstein College of Medicine, Bronx, NY), Hawley, R.S
Format: Article
Language:English
Subjects:
Alleles
Animals
Biological and medical sciences
CHROMOSOME
Chromosome Mapping
Chromosomes
Classical genetics, quantitative genetics, hybrids
CLONACION
CLONAGE
CODE GENETIQUE
CODIGO GENETICO
CROISEMENT
CROMOSOMAS
Crosses, Genetic
CRUZAMIENTO
Diptera
DROSOPHILA MELANOGASTER
Drosophila melanogaster - genetics
Drosophilidae
Enhancer Elements, Genetic
Female
Female animals
Fundamental and applied biological sciences. Psychology
Genes, Dominant
Genes, Recessive
Genetic Complementation Test
Genetic loci
Genetic mutation
Genetics of eukaryotes. Biological and molecular evolution
GENOTIPOS
GENOTYPE
Heterozygotes
Homozygote
Invertebrata
LOCI
LOCUS
Male
Medical genetics
MEIOSE
MEIOSIS
Microtubule Proteins - genetics
Mitosis
MUTACION
MUTATION
Nondisjunction, Genetic
Sex chromosomes
X Chromosome
Y Chromosome
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Description
Summary:The nod (no distributive disjunction) and the ncd (non-claret disjunctional) mutations are both female-specific, recessive meiotic mutations in Drosophila melanogaster. Mutations at either locus show high frequencies of nondisjunction at meiosis I and both have been shown to encode kinesin-like proteins. Unlike the ncd mutation, which affects all chromosome pairs, the nod mutation affects only the disjunction of nonexchange chromosomes. Although both the nod and ncd mutations are fully recessive, females doubly heterozygous for nod and ncd mutations show levels of X and fourth chromosome nondisjunction that are 6- to 35-fold above those observed in control females. Exchange between chromosomes can suppress this effect; thus, only nonexchange chromosomes segregating via the distributive system are sensitive in double heterozygotes. Since the phenotype of double heterozygotes mimics that of the nod mutation, we infer that ncd is a dominant enhancer of nod. Failure of ncd to fully complement nod reveals the chromosome segregation machinery to be dosage sensitive. The probability that the distributive system will fail is enhanced in females simultaneously haploinsufficient at the nod and ncd loci.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.88.16.7165