Hematopoietic cell culture therapies (Part II): clinical aspects and applications

High-dose chemotherapy, followed by hematopoietic stem cell transplantation, holds significant promise for increasing the probability of long-term remission and possibly cure in a variety of cancers. Hematopoietic cell culture, or ex vivo expansion of hematopoietic cells, may play a significant role...

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Bibliographic Details
Published in:Trends in biotechnology (Regular ed.) 1996-10, Vol.14 (10), p.388-396
Main Authors: A. McAdams, Todd, N. Winter, Jane, M. Miller, William, Terry Papoutsakis, E.
Format: Article
Language:English
Subjects:
Animal cells
Antigens, CD34 - metabolism
Biological and medical sciences
Biotechnology
Biotechnology - trends
Bone Marrow Transplantation
Cells, Cultured
Clinical Trials as Topic - trends
Combined Modality Therapy
Eukaryotic cell cultures
Fetal Blood - cytology
Fundamental and applied biological sciences. Psychology
Graft Survival
Hematopoietic Stem Cell Transplantation - trends
Hematopoietic System - cytology
Hematopoietic System - immunology
Humans
Methods. Procedures. Technologies
Miscellaneous
Neoplasms - therapy
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Summary:High-dose chemotherapy, followed by hematopoietic stem cell transplantation, holds significant promise for increasing the probability of long-term remission and possibly cure in a variety of cancers. Hematopoietic cell culture, or ex vivo expansion of hematopoietic cells, may play a significant role in reducing the danger and expense associated with the transplantation procedure. Phase I clinical trials have shown that ex vivo expanded cells have no significant toxicities, and some benefits. Ex vivo expansion of hematopoietic cells is likely to find other applications in gene therapy, tumor purging, production of dendritic cells for immunotherapy and the production of mature blood cells for transfusion therapies.
ISSN:0167-7799
1879-3096
DOI:10.1016/0167-7799(96)10054-8