Allelotype of renal cell carcinoma

Several recent studies based on restriction fragment length polymorphism analysis have supported the concept that the accumulation of multiple genetic alterations converts a normal cell to a malignant cell. Activation of oncogenes and/or inactivation of tumor suppressor genes have been observed duri...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1991-02, Vol.51 (3), p.820-823
Main Authors: MORITA, R, ISHIKAWA, J, TSUTSUMI, M, KIKIJI, K, TSUKADA, Y, KAMIDONO, S, MAEDA, S, NAKAMURA, Y
Format: Article
Language:English
Subjects:
Biological and medical sciences
Carcinoma, Renal Cell - genetics
chromosome 3
Chromosome Mapping
Genes, Suppressor - genetics
Heterozygote
Humans
kidney
Kidney Neoplasms - genetics
Kidneys
Medical sciences
Nephrology. Urinary tract diseases
Polymorphism, Restriction Fragment Length
restriction fragment length polymorphism
suppressor genes
Tumors of the urinary system
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Summary:Several recent studies based on restriction fragment length polymorphism analysis have supported the concept that the accumulation of multiple genetic alterations converts a normal cell to a malignant cell. Activation of oncogenes and/or inactivation of tumor suppressor genes have been observed during tumor progression in colorectal cancer, lung cancer, and breast cancer. To investigate the possibility that multiple genes are altered during the progression of renal cell carcinoma, we have used restriction fragment length polymorphism markers throughout the genome to test for loss of heterozygosity in 38 renal cell carcinomas. Nearly 64% of the tumors had lost heterozygosity on the short arm of chromosome 3. We also observed loss of heterozygosity averaging about 30% at informative loci on six other chromosomal arms (chromosomes 5q, 6q, 10q, 11q, 17p, and 19p). These results lead us to suspect the existence of several tumor suppressor genes associated with carcinogenesis of renal cell carcinoma.
ISSN:0008-5472
1538-7445