Changes in specific binding sites of girisopam after chemical and surgical lesions in the striato-nigral system

Neurotoxin (AMPA)-induced lesions in the caudate nucleus as well as unilateral surgical transection of the striato-nigral pathway strongly depleted the binding of a homophthalazine (formerly called 2,3-benzodiazepines) girisopam (GYKI-51189, EGIS 5810) selectively in the substantia nigra of the rat,...

Full description

Saved in:
Bibliographic Details
Published in:Brain research. Molecular brain research. 1997-04, Vol.45 (1), p.141-144
Main Authors: Horváth, Edit J., Fekete, Márton I.K., Palkovits, Miklós
Format: Article
Language:English
Subjects:
2,3-Benzodiazepine
Afferent Pathways - physiology
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - toxicity
AMP
Animals
Anti-Anxiety Agents - metabolism
Autoradiography
Benzodiazepines - metabolism
Binding Sites
Biological and medical sciences
Caudate Nucleus - drug effects
Caudate Nucleus - pathology
Caudate Nucleus - physiology
Girisopam
Globus Pallidus - drug effects
Globus Pallidus - pathology
Globus Pallidus - physiology
Male
Medical sciences
Neuropharmacology
Neurotoxins - toxicity
Nucleus Accumbens - drug effects
Nucleus Accumbens - pathology
Nucleus Accumbens - physiology
Pharmacology. Drug treatments
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Rats
Rats, Sprague-Dawley
Receptors, GABA-A - metabolism
Striatal lesion
Striato-nigral transection
Substantia Nigra - drug effects
Substantia Nigra - pathology
Substantia Nigra - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Neurotoxin (AMPA)-induced lesions in the caudate nucleus as well as unilateral surgical transection of the striato-nigral pathway strongly depleted the binding of a homophthalazine (formerly called 2,3-benzodiazepines) girisopam (GYKI-51189, EGIS 5810) selectively in the substantia nigra of the rat, ipsilateral to the lesions. In contrast to this, AMPA injections into the substantia nigra failed to effect on girisopam binding to either components of the nigro-striatal system. Data indicate that this homophthalazine may bind to a descending component of the striatum (striato-nigral projecting neurons), or its binding capacity to substantia nigra neurons depends on the integrity of striatal afferent pathways to the substantia nigra.
ISSN:0169-328X
1872-6941
DOI:10.1016/S0169-328X(96)00293-8