Bone marrow mast cell density correlates with serum levels of VEGF and CXC chemokines ENA-78 and GRO-α in multiple myeloma

Angiogenesis is a crucial process in growth and progression of multiple myeloma (MM). Mast cells (MCs) play an important role in MM angiogenesis. Various angiogenic mediators secreted by MCs regulate endothelial cell proliferation and function. Among them, ELR + CXC chemokines, such as growth-relate...

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Bibliographic Details
Published in:Tumor biology 2014-06, Vol.35 (6), p.5647-5651
Main Authors: Pappa, C. A., Tsirakis, G., Devetzoglou, M., Zafeiri, M., Vyzoukaki, R., Androvitsanea, A., Xekalou, A., Sfiridaki, K., Alexandrakis, M. G.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomedical and Life Sciences
Biomedicine
Bone Marrow Cells - physiology
Cancer Research
Cell Count
Chemokine CXCL1 - blood
Chemokine CXCL5 - blood
Female
Humans
Male
Mast Cells - physiology
Middle Aged
Multiple Myeloma - blood
Multiple Myeloma - pathology
Research Article
Vascular Endothelial Growth Factor A - blood
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Summary:Angiogenesis is a crucial process in growth and progression of multiple myeloma (MM). Mast cells (MCs) play an important role in MM angiogenesis. Various angiogenic mediators secreted by MCs regulate endothelial cell proliferation and function. Among them, ELR + CXC chemokines, such as growth-related oncogen-alpha (GRO-α) and epithelial neutrophil activating protein-78 (ENA-78), have been described as potential mediators in regulation of angiogenesis. The purpose of the study was to quantify MCs in bone marrow (BM) biopsies of MM patients, expressed as MC density (MCD), and correlate it with serum concentrations of vascular endothelial factor (VEGF), GRO-α, ENA-78. Fifty-four newly diagnosed MM patients and 22 healthy controls were studied. Tryptase was used for the immunohistochemical stain of MCs. VEGF, GRO-α, and ENA-78 were measured in sera by ELISA. MCD and serum levels of GRO-α, ENA-78, and VEGF were significantly higher in MM patients compared to controls ( p  
ISSN:1010-4283
1423-0380
DOI:10.1007/s13277-014-1747-x