Iatrogenic pancreatitis in patients with IPMN after ERCP: incidence and predictive signs

Background and aims The prevalence of intraductal papillary mucinous neoplasm (IPMN) has recently increased, and endoscopic retrograde cholangiopancreatography (ERCP) is a major diagnostic modality for IPMN. The aim of our study was to determine the prevalence rate of iatrogenic pancreatitis in the...

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Bibliographic Details
Published in:Abdominal imaging 2014-10, Vol.39 (5), p.949-954
Main Authors: Jung, Min Kyu, Jang, Yun-Jin, Cho, Chang Min, Kim, Gab Chul, Cho, Seung Hyun, Lee, Dakeun, Ryeom, Hun Kyu, Shin, Kyung Min
Format: Article
Language:English
Subjects:
Adenocarcinoma, Mucinous - diagnostic imaging
Adenocarcinoma, Mucinous - epidemiology
Adult
Aged
Aged, 80 and over
Carcinoma, Pancreatic Ductal - diagnostic imaging
Carcinoma, Pancreatic Ductal - epidemiology
Cholangiopancreatography, Endoscopic Retrograde - methods
Female
Gastroenterology
Hepatology
Humans
Iatrogenic Disease - epidemiology
Imaging
Incidence
Male
Medicine
Medicine & Public Health
Middle Aged
Pancreatic Ducts - diagnostic imaging
Pancreatic Neoplasms - diagnostic imaging
Pancreatic Neoplasms - epidemiology
Pancreatitis - diagnostic imaging
Pancreatitis - epidemiology
Predictive Value of Tests
Prevalence
Radiology
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Summary:Background and aims The prevalence of intraductal papillary mucinous neoplasm (IPMN) has recently increased, and endoscopic retrograde cholangiopancreatography (ERCP) is a major diagnostic modality for IPMN. The aim of our study was to determine the prevalence rate of iatrogenic pancreatitis in the patients with IPMN and the predictive signs on pre-procedural images and endoscopic procedures. Patients and methods At a single center, patients who underwent ERCP between September 2001 and December 2010 were included in this study. The presence of iatrogenic pancreatitis was evaluated and the difference of prevalence in the patients with/without IPMN was determined. Then, a review of cross-sectional images was performed. Results The prevalence rate of iatrogenic pancreatitis in the patients with IPMN was 20% and that in the patients with other pancreatic cystic lesions was 14%. Mural nodules on images and filling defects on ERCP were more highly detected in the patients without iatrogenic pancreatitis ( p  = 0.040 and p  = 0.027, respectively). In the multivariate analysis, the presence of filling defects correlated with a decreased incidence of iatrogenic pancreatitis (odds ratio = 0.119 and p = 0.047). Conclusion In this study, the prevalence rate of ERCP-induced pancreatitis in the patients with IPMN was 21%, and the presence of filling defects was associated with a decreased incidence of iatrogenic pancreatitis.
ISSN:0942-8925
2366-004X
1432-0509
2366-0058
DOI:10.1007/s00261-014-0122-0