High need for MMR vaccination in HIV infected adults in Austria

Abstract Current guidelines recommend screening for HIV infected patients susceptible for vaccine preventable diseases and offering of immunization. However, data regarding the vaccination coverage among this group are largely missing. This study analyzed the serostatus for Measles, Mumps and Rubell...

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Bibliographic Details
Published in:Vaccine 2014-10, Vol.32 (45), p.6020-6023
Main Authors: Grabmeier-Pfistershammer, K, Poeppl, W, Herkner, H, Touzeau-Roemer, V, Huschka, Emilia, Rieger, A, Burgmann, H
Format: Article
Language:English
Subjects:
Adult
Age
Allergy and Immunology
Antibodies, Viral - blood
Antiretroviral Therapy, Highly Active
Applied microbiology
Austria - epidemiology
Biological and medical sciences
CD4 Lymphocyte Count
Confidence intervals
Cross-Sectional Studies
Female
Fundamental and applied biological sciences. Psychology
Health Services Needs and Demand
HIV
HIV Infections - drug therapy
HIV Infections - epidemiology
Human immunodeficiency virus
Human viral diseases
Humans
Hypotheses
Hypothesis testing
Immunodeficiency
Immunoglobulin G - blood
Infections
Infectious diseases
Logistic Models
Male
Measles
Measles - prevention & control
Measles-Mumps-Rubella Vaccine - therapeutic use
Medical sciences
Microbiology
Middle Aged
Migration
Miscellaneous
MMR
Multivariate Analysis
Mumps
Mumps - prevention & control
Prevention
Rubella - prevention & control
Vaccination
Vaccination - statistics & numerical data
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Virology
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Summary:Abstract Current guidelines recommend screening for HIV infected patients susceptible for vaccine preventable diseases and offering of immunization. However, data regarding the vaccination coverage among this group are largely missing. This study analyzed the serostatus for Measles, Mumps and Rubella of more than 700 HIV infected patients residing in Austria. These patients were representative for the Austrian HIV cohort regarding sex, age, transmission risk and HIV progression markers. 73.6% were on suppressive HAART, mean CD4 cell count was 603 c/μl. Seronegativity was 8.4% for Measles, 33.4% for Mumps and 18.8% for Rubella. In total, out of the 713 HIV infected adults analyzed, almost half (47.8%) would require MMR vaccination. In a multivariate analysis migration was significantly associated with seronegativity for Measles (OR 0.5, CI 0.27–0.9) and Mumps (OR 0.57, CI 0.39–0.81). Importantly due to the well preserved immune status of nearly all participants vaccination would be feasible in the majority of the seronegative patients. Thus, a proactive approach would largely reduce the number of patients at risk for vaccine-preventable diseases.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2014.07.114