Sensing viral invasion by RIG-I like receptors

Highlights • RLRs are viral sensors that recognize cytoplasmic non-self RNA. • IFN signaling is induced by RLRs through unique and common sensing mechanisms. • Biochemical properties of RNA are an important determinant of RLR activation. • Multiple biological processes are required for the efficient...

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Bibliographic Details
Published in:Current opinion in microbiology 2014-08, Vol.20, p.131-138
Main Authors: Yoo, Ji-Seung, Kato, Hiroki, Fujita, Takashi
Format: Article
Language:English
Subjects:
Animals
Cytokines - immunology
Cytokines - secretion
DEAD-box RNA Helicases - immunology
DEAD-box RNA Helicases - metabolism
Host-Pathogen Interactions
Humans
Immunity, Innate
Mammals
Pathology
Receptors, Immunologic - immunology
Receptors, Immunologic - metabolism
RNA, Viral - immunology
RNA, Viral - metabolism
Viruses - immunology
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Description
Summary:Highlights • RLRs are viral sensors that recognize cytoplasmic non-self RNA. • IFN signaling is induced by RLRs through unique and common sensing mechanisms. • Biochemical properties of RNA are an important determinant of RLR activation. • Multiple biological processes are required for the efficient IFN signaling.
ISSN:1369-5274
1879-0364
DOI:10.1016/j.mib.2014.05.011