Loading…
Body mass index and biliary tract disease: A systematic review and meta-analysis of prospective studies
Abstract Objective To evaluate the association between body mass index (BMI, kg/m2 ) and incidence of biliary tract disease. Methods We performed a systematic review and a meta-analysis of prospective studies by searching the database of PubMed and EMBASE published up to December 31, 2013. Outcome o...
Saved in:
Published in: | Preventive medicine 2014-08, Vol.65, p.13-22 |
---|---|
Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | Abstract Objective To evaluate the association between body mass index (BMI, kg/m2 ) and incidence of biliary tract disease. Methods We performed a systematic review and a meta-analysis of prospective studies by searching the database of PubMed and EMBASE published up to December 31, 2013. Outcome of interest was disease of biliary tract system (gallbladder, extrahepatic bile duct and Ampullar of Vater). We used a random-effects model to combine the study-specific relative risks (RRs) and 95% confidence intervals (95% CIs) from 22 prospective studies. We examined whether BMI was associated with a higher risk of biliary tract disease in a combined analysis. Results The positive association was stronger for non-cancer biliary tract disease than biliary tract cancer; combined RRs (95% CIs) comparing the top with bottom categories were 1.40 (1.15–1.65) for biliary tract cancer and 2.75 (2.35–3.15) for non-cancer biliary tract disease ( P for difference < 0.001). For non-cancer biliary tract disease, combined RRs (95% CIs) comparing the top with bottom categories were 3.21 (2.48–3.93) for women and 2.01 (1.66–2.37) for men ( P for difference = 0.04). Conclusion Obesity is associated with higher risks of biliary tract cancer and, to a greater extent, non-cancer biliary tract disease. |
---|---|
ISSN: | 0091-7435 1096-0260 |
DOI: | 10.1016/j.ypmed.2014.03.027 |