Evaluation of bone metastases from breast cancer by bone scintigraphy and positron emission tomography/computed tomography imaging

Abstract Objective The aim of this study was to compare bone scintigraphy (BS) and positron emission tomography/computed tomography (PET/CT) for the detection of bone metastases from breast cancer. Study design Twenty patients with breast cancer and bone pain were submitted to both bone scintigraphy...

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Bibliographic Details
Published in:European journal of obstetrics & gynecology and reproductive biology 2014-09, Vol.180, p.138-141
Main Authors: Pires, Ary O, Borges, Umbelina S, Lopes-Costa, Pedro V, Gebrim, Luiz H, da Silva, Benedito B
Format: Article
Language:English
Subjects:
Bone metastases
Bone Neoplasms - diagnostic imaging
Bone Neoplasms - secondary
Bone scintigraphy
Breast
Breast Neoplasms - pathology
Cancer
Carcinoma - diagnostic imaging
Carcinoma - secondary
Female
Fluorodeoxyglucose F18
Humans
Middle Aged
Multimodal Imaging
Obstetrics and Gynecology
PET/CT
Positron-Emission Tomography
Radionuclide Imaging
Radiopharmaceuticals
Sensitivity and Specificity
Technetium Tc 99m Medronate
Tomography, X-Ray Computed
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Summary:Abstract Objective The aim of this study was to compare bone scintigraphy (BS) and positron emission tomography/computed tomography (PET/CT) for the detection of bone metastases from breast cancer. Study design Twenty patients with breast cancer and bone pain were submitted to both bone scintigraphy and 18-F-fluorodeoxyglucose PET/CT imaging between July 2012 and June 2013. Scintigraphy was performed following an intravenous injection of technetium-99m-methylene diphosphonate (99mTc-MDP) around 10 days before the PET/CT scan, performed using an intravenous injection of 18-F-fluorodeoxyglucose followed by whole-body computed tomography (CT) to characterize metastases by both methods. Student's t -test for paired samples was used in the comparative data analysis, with significance at p < 0.05. Results CT identified 429 metastatic implants in the 20 patients, with scintigraphy showing 244 of these lesions (57%) and PET/CT showing 307 (72%); however, there was no statistically significant difference between the mean number of lesions detected per patient with the two imaging modalities ( p = 0.367). Conclusion In the present study, no difference was found between PET/CT and bone scintigraphy in the detection of bone metastases from breast cancer.
ISSN:0301-2115
1872-7654
DOI:10.1016/j.ejogrb.2014.06.021