Evaluation of corneal epithelial and stromal thickness in keratoconus using spectral-domain optical coherence tomography

Purpose We sought to assess the corneal thickness of the epithelium and stroma in keratoconic and normal eyes by spectral-domain optical coherence tomography (SD-OCT). Methods Fifty-seven keratoconic and 20 normal eyes were studied. The eyes were examined by SD-OCT, and the keratoconic eyes were sub...

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Bibliographic Details
Published in:Japanese journal of ophthalmology 2014-09, Vol.58 (5), p.389-395
Main Authors: Maeda, Naoyuki, Nakagawa, Tomoya, Higashiura, Ritsuko, Fuchihata, Mutsumi, Koh, Shizuka, Nishida, Kohji
Format: Article
Language:English
Subjects:
Adult
Clinical Investigation
Corneal Stroma - pathology
Cross-Sectional Studies
Epithelium, Corneal - pathology
Female
Humans
Keratoconus - pathology
Male
Medicine
Medicine & Public Health
Middle Aged
Ophthalmology
Tomography, Optical Coherence
Young Adult
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Summary:Purpose We sought to assess the corneal thickness of the epithelium and stroma in keratoconic and normal eyes by spectral-domain optical coherence tomography (SD-OCT). Methods Fifty-seven keratoconic and 20 normal eyes were studied. The eyes were examined by SD-OCT, and the keratoconic eyes were subdivided into 2 groups: those showing only smooth corneal thinning and corneal protrusion on the image (KC1 group) and those showing abnormalities in the Bowman layer or in the stroma, or in both (KC2 group). The thicknesses at the corneal vertex and at the superior, inferior, nasal, and temporal cornea 1.5 mm from the corneal vertex in the KC1 group were compared with those in the normal group. The OCT findings in the KC2 group were described. Results The epithelial thickness at the corneal vertex and at the inferior and temporal cornea, and the stromal thickness at all points were significantly thinner in the KC1 group than in the normal group ( p  
ISSN:0021-5155
1613-2246
DOI:10.1007/s10384-014-0338-0