Influence of AKT on progesterone action in endometrial diseases

Progesterone plays an essential role in the maintenance of the endometrium; it prepares the endometrium for pregnancy, promotes decidualization, and inhibits estrogen-dependent proliferation. Progesterone function is often dysregulated in endometrial disease states. In addition, the PI3K/AKT signali...

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Bibliographic Details
Published in:Biology of reproduction 2014-09, Vol.91 (3), p.63-63
Main Authors: Lee, Irene I, Kim, J Julie
Format: Article
Language:English
Subjects:
Animals
Cell Proliferation - drug effects
Endometrium - drug effects
Endometrium - metabolism
Endometrium - pathology
Female
Humans
Progesterone - therapeutic use
Progestins - therapeutic use
Proto-Oncogene Proteins c-akt - metabolism
Receptors, Progesterone - agonists
Receptors, Progesterone - metabolism
Signal Transduction - drug effects
Uterine Diseases - drug therapy
Uterine Diseases - metabolism
Uterine Diseases - pathology
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Summary:Progesterone plays an essential role in the maintenance of the endometrium; it prepares the endometrium for pregnancy, promotes decidualization, and inhibits estrogen-dependent proliferation. Progesterone function is often dysregulated in endometrial disease states. In addition, the PI3K/AKT signaling pathway is often overactive in endometrial pathologies and promotes the survival and proliferation of the diseased cells. Understanding how AKT influences progesterone action is critical in improving hormone-based therapies in endometrial pathologies. Here, we summarize recent studies investigating the crosstalk between the AKT pathway and progesterone receptor function in endometriosis and endometrial cancer.
ISSN:0006-3363
1529-7268
DOI:10.1095/biolreprod.114.119255