Association Between Alcohol Consumption and Risk of Cardiovascular Disease and All-Cause Mortality in Patients With Hypertension: A Meta-Analysis of Prospective Cohort Studies

Abstract Objective To conduct a meta-analysis summarizing the risk of cardiovascular disease (CVD) and all-cause mortality (ACM) in relation to alcohol consumption in patients with hypertension, focusing on clarifying dose-response associations. Patients and Methods PubMed and EMBASE were searched f...

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Bibliographic Details
Published in:Mayo Clinic proceedings 2014-09, Vol.89 (9), p.1201-1210
Main Authors: Huang, Chao, BS, Zhan, Jian, MPH, Liu, Yu-Jian, MPH, Li, De-Jia, PhD, Wang, Su-Qing, PhD, He, Qi-Qiang, PhD
Format: Article
Language:English
Subjects:
Alcohol Drinking - adverse effects
Alcohol Drinking - epidemiology
Cardiovascular Diseases - mortality
Care and treatment
Complications and side effects
Development and progression
Dose-Response Relationship, Drug
Drinking of alcoholic beverages
Female
Humans
Hypertension
Hypertension - mortality
Internal Medicine
Male
Meta-analysis
Prospective Studies
Risk
Risk Factors
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Summary:Abstract Objective To conduct a meta-analysis summarizing the risk of cardiovascular disease (CVD) and all-cause mortality (ACM) in relation to alcohol consumption in patients with hypertension, focusing on clarifying dose-response associations. Patients and Methods PubMed and EMBASE were searched for eligible prospective cohort studies from December 3, 1949, through January 18, 2014. The semi-parameter method and dose-response analysis were used. Results Nine studies (11 cohorts) were included in the meta-analysis. Compared with the lowest alcohol level (abstainers/occasional drinkers), the pooled relative risk (RR) was 0.72 (95% CI, 0.68-0.77) for the third highest category (median, 10 g/d), 0.81 (95% CI, 0.71-0.93) for the second highest category (median, 20 g/d), and 0.60 (95% CI, 0.54-0.67) for the highest category (median, 30 g/d). A J-shaped relationship between alcohol use and ACM was observed, and the nadir (RR, 0.82; 95% CI, 0.76-0.88) was found to be at a dose of 8 to 10 g of alcohol consumption per day. Conclusion Findings of this meta-analysis suggest that low-to-moderate alcohol consumption was inversely significantly associated with the risk of CVD and ACM in patients with hypertension.
ISSN:0025-6196
1942-5546
DOI:10.1016/j.mayocp.2014.05.014