Active surveillance of adverse events following childhood immunization in Singapore

Highlights • Historical passive reporting of adverse events following immunization (AEFI) underestimates cases. • We conducted a hospital-based active surveillance that detected increases in BCG-associated lymphadenitis. • Such surveillance can enhance signal detection and follow-up investigations o...

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Bibliographic Details
Published in:Vaccine 2014-09, Vol.32 (39), p.5000-5005
Main Authors: Thoon, Koh Cheng, Soh, Sally Bee Leng, Liew, Woei Kang, Gunachandran, Arunan, Tan, Natalie Woon Hui, Chong, Chia Yin, Yung, Chee Fu
Format: Article
Language:English
Subjects:
Adverse Drug Reaction Reporting Systems
Adverse events following immunization
Allergy and Immunology
Applied microbiology
BCG Vaccine - adverse effects
Biological and medical sciences
Causality
Children
Children & youth
Female
Fundamental and applied biological sciences. Psychology
Hospitals
Humans
Immunization
Infant
Lymphadenitis - chemically induced
Male
Microbiology
Population Surveillance - methods
Singapore
Vaccination - adverse effects
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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Summary:Highlights • Historical passive reporting of adverse events following immunization (AEFI) underestimates cases. • We conducted a hospital-based active surveillance that detected increases in BCG-associated lymphadenitis. • Such surveillance can enhance signal detection and follow-up investigations of AEFI. • This enhances public and physician confidence in vaccination programmes. • It also improves understanding of risk-benefit ratios of specific vaccines.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2014.07.020