Compressive mechanical properties of atherosclerotic plaques—Indentation test to characterise the local anisotropic behaviour

Abstract Accurate material models and associated parameters of atherosclerotic plaques are crucial for reliable biomechanical plaque prediction models. These biomechanical models have the potential to increase our understanding of plaque progression and failure, possibly improving risk assessment of...

Full description

Saved in:
Bibliographic Details
Published in:Journal of biomechanics 2014-03, Vol.47 (4), p.784-792
Main Authors: Chai, Chen-Ket, Speelman, Lambert, Oomens, Cees W.J, Baaijens, Frank P.T
Format: Article
Language:English
Subjects:
Anisotropy
Atherosclerosis
Atherosclerosis - physiopathology
Biomechanical Phenomena - physiology
Biomechanics
Blood clots
Compressing
Compressive properties
Coronary vessels
Experiments
Finite element method
Heart attacks
Humans
Indentation
Inverse
Lipids
Mathematical models
Mechanical properties
Methods
Myocardial infarction
Physical Medicine and Rehabilitation
Plaque rupture
Plaque, Atherosclerotic - physiopathology
Risk assessment
Rupture, Spontaneous
Stress, Mechanical
Studies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Accurate material models and associated parameters of atherosclerotic plaques are crucial for reliable biomechanical plaque prediction models. These biomechanical models have the potential to increase our understanding of plaque progression and failure, possibly improving risk assessment of plaque rupture, which is the main cause of ischaemic strokes and myocardial infarction. However, experimental biomechanical data on atherosclerotic plaque tissue is scarce and shows a high variability. In addition, most of the biomechanical models assume isotropic behaviour of plaque tissue, which is a general over-simplification. This review discusses the past and the current literature that focus on mechanical properties of plaque derived from compression experiments, using unconfined compression, micro-indentation or nano-indentation. Results will be discussed and the techniques will be mutually compared. Thereafter, an in-house developed indentation method combined with an inverse finite element method is introduced, allowing analysis of the local anisotropic mechanical properties of atherosclerotic plaques. The advantages and limitations of this method will be evaluated and compared to other methods reported in literature.
ISSN:0021-9290
1873-2380
DOI:10.1016/j.jbiomech.2014.01.018